Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Trina A. Johnson"'
Publikováno v:
BioTechniques, Vol 31, Iss 4, Pp 740-742 (2001)
Externí odkaz:
https://doaj.org/article/de6fa5d357eb4264b2765f4c1294f1af
Autor:
Ayal Rozenberg, Brenda Banwell, Julia O'Mahony, Trina A. Johnson, Heather Hanwell, Luke M. Healy, Alexander W Saveriano, Ina Mexhitaj, Mukanthu Nyirenda, Giulia Fadda, Rui Li, Douglas L. Arnold, Craig S. Moore, Shannon E. Dunn, Amit Bar-Or, Chahrazed Belabani, E. Ann Yeh, Laurence Poliquin-Lasnier, Ruth Ann Marrie
Publikováno v:
Multiple sclerosis (Houndmills, Basingstoke, England). 27(12)
Background: Being obese is associated with both increased risk of developing multiple sclerosis (MS) and greater MS disease activity. Objectives: The objective of this study is to investigate levels and potential pathophysiologic contribution of seru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd038f61885b55540839506365214ad4
https://pubmed.ncbi.nlm.nih.gov/33522403
https://pubmed.ncbi.nlm.nih.gov/33522403
Autor:
Ina Mexhitaj, Ruth Ann Marrie, Trina A. Johnson, Dessa Sadovnick, Ayman Rezk, Amit Bar-Or, D. Louis Collins, Douglas L. Arnold, Ayal Rozenberg, Brenda Banwell, Julia O'Mahony, Craig S. Moore, Rui Li, Mukanthu Nyirenda, Bruno Gran, E. Ann Yeh
Publikováno v:
Brain : a journal of neurology. 142(3)
Elucidation of distinct T-cell subsets involved in multiple sclerosis immune-pathophysiology continues to be of considerable interest since an ultimate goal is to more selectively target the aberrant immune response operating in individual patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509c66e627dfd2ad67e0c3a2fde37055
https://pubmed.ncbi.nlm.nih.gov/30810210
https://pubmed.ncbi.nlm.nih.gov/30810210
Autor:
Timucin Avsar, Trina A. Johnson, Roberto Alvarez-Lafuente, Guillermo Izquierdo, Oscar Fernandez, Clara de Andrés, Manuel Comabella, Bonaventura Casanova, E. P. Evdoshenko, Francisco Coret, Maria Isabel García-Sánchez, Nadia Ouamara, Xavier Montalban, José C. Álvarez-Cermeño, Aksel Siva, Amit Bar-Or, Farzaneh Jalili, David Leppert, Donna Masterman, Rafael Arroyo, Sergey V. Lapin, Luisa M. Villar
Publikováno v:
Annals of Neurology. 76:231-240
Objective To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. Methods The presence or absence of both immunoglobulin (Ig) G and IgM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2afa43632a5e76f9eda1fb74579e51c7
https://doi.org/10.1002/ana.24190
https://doi.org/10.1002/ana.24190
Autor:
David Henault, Trina A. Johnson, Lorna Galleguillos, Amit Bar-Or, Jack P. Antel, Craig S. Moore
Publikováno v:
Neurology. 81:1768-1772
Objective: To determine the range of fluctuation in total lymphocyte counts (TLCs) in peripheral blood over a 4- to 7-year period in patients with MS receiving fingolimod (FTY720) and the relation between TLCs and T-cell subsets (CD4+, CD8+, CCR7+/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d77c0fc4189c0dd75ca4d4a9cf4c679
https://doi.org/10.1212/01.wnl.0000435564.92609.2c
https://doi.org/10.1212/01.wnl.0000435564.92609.2c
Autor:
Craig S. Moore, Domenick A. Zammit, Bryce A. Durafourt, Amit Bar-Or, Marie-Christine Guiot, Jack P. Antel, Trina A. Johnson, Fatma Zaguia
Publikováno v:
Glia. 60:717-727
Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood-derived macrophages participate in inflammatory responses in the CNS. Macrophages can be polarized into M1 and M2 phenotypes, which have been linked to functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001be0c6c3241d046aa0009bf2a26052
https://doi.org/10.1002/glia.22298
https://doi.org/10.1002/glia.22298
Publikováno v:
Neurology. 76:S20-S27
The oral sphingosine 1-phosphate (S1P) receptor (S1PR) modulator fingolimod has been shown to be effective in the treatment of patients with relapsing multiple sclerosis (MS). The drug binds with high affinity to 4 of the 5 G-protein-coupled S1P rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a907e3cbe041f27364f4947be4da44cc
https://doi.org/10.1212/wnl.0b013e31820db341
https://doi.org/10.1212/wnl.0b013e31820db341
Autor:
Mark R. Keezer, Yves Lapierre, Igor Shames, David G. Haegert, Amit Bar-Or, Trina A. Johnson, Jack P. Antel
Publikováno v:
Clinical Immunology. 137:15-20
FTY720 (Fingolimod) reduces multiple sclerosis disease activity by inducing lymphopenia and inhibiting lymphocyte re-entry from lymph nodes. Peripheral lymphocyte reconstitution following drug discontinuation has been considered relatively rapid (2-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d0a5351de5ff948b17cc6ad8b7e057
https://doi.org/10.1016/j.clim.2010.06.005
https://doi.org/10.1016/j.clim.2010.06.005
Publikováno v:
The American Journal of Pathology. 173:1029-1041
Although the physiological roles of the cellular prion protein (PrP C) remain to be fully elucidated, PrP C has been proposed to represent a potential regulator of cellular immunity. To test this hypothesis, we evaluated the consequences of PrP C def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae465c23b6f9777654d9912f60f8c0a
https://doi.org/10.2353/ajpath.2008.071062
https://doi.org/10.2353/ajpath.2008.071062
Publikováno v:
The American Journal of Pathology. 172:980-992
The Pten tumor suppressor gene is critical for normal intrathymic development of T cells; however, its role in mature antigen-activated T cells is less well defined. A genetically crossed mouse line, Pten(fl/fl) GBC, in which Pten gene deletions coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a851fd8e929052a7b07e38423e7bbf4b
https://doi.org/10.2353/ajpath.2008.070892
https://doi.org/10.2353/ajpath.2008.070892