Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Trimethylenemethane cycloaddition"'
Publikováno v:
Organic Letters. 20:3938-3942
The use of β-nitroenamines as a new class of acceptors in the enantioselective Pd-catalyzed trimethylenemethane cycloaddition afforded differentiated 1,2-dinitrogen bearing cyclopentanes with three contiguous stereocenters. The utility of these acce
Autor:
Laurent Debien, Barry M. Trost
Publikováno v:
ChemInform. 47
α-Trifluoromethyl-styrenes, trifluoromethyl-enynes, and dienes undergo palladium-catalyzed trimethylenemethane cycloadditions under mild reaction conditions. The trifluoromethyl group serves as a unique σ-electron-withdrawing group for the activati
Publikováno v:
Journal of the American Chemical Society. 133:19483-19497
A protocol for the enantioselective [3+2] cycloaddition of trimethylenemethane (TMM) with electron-deficient olefins has been developed. The synthesis of novel phosphoramidite ligands was critical in this effort, and the preparation and reactivity of
Autor:
Laurent Debien, Barry M. Trost
Publikováno v:
Journal of the American Chemical Society. 137(36)
α-Trifluoromethyl-styrenes, trifluoromethyl-enynes, and dienes undergo palladium-catalyzed trimethylenemethane cycloadditions under mild reaction conditions. The trifluoromethyl group serves as a unique σ-electron-withdrawing group for the activati
Publikováno v:
ChemInform. 46
The title reaction proceeds without subsequent rearomatization and can be applied on a broad range of heterocyclic and benzoid substrates.
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Publikováno v:
Journal of the American Chemical Society. 136(23)
A general protocol for the palladium-catalyzed dearomative trimethylenemethane [3+2] cycloaddition reaction with simple nitroarene substrates is described. This methodology leads to the exclusive formation of the dearomatized alicyclic products witho
Publikováno v:
ChemInform. 45
The title reaction provides a synthesis of marcofortines, which are potent anthelmintic active metabolites.
Publikováno v:
Journal of the American Chemical Society. 121:9313-9317
Carbon kinetic isotope effects were determined at natural abundance for the palladium trimethylenemethane cycloaddition of ester−amide 5. Substantial intermolecular 13C KIEs were observed for both olefinic carbons of 5. In contrast, a Michael addit
Publikováno v:
Journal of the American Chemical Society. 135(44)
The marcfortines are complex secondary metabolites that show potent anthelmintic activity and are characterized by the presence of a bicyclo[2.2.2]diazaoctane fused to a spirooxindole. Herein, we report the synthesis of two members of this family. Th