Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

Autor: Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond

Publikováno v: eLife, Vol 6 (2017)

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by

Externí odkaz: https://doaj.org/article/5511bcb97c1940439d260bcc3a89f1d7

Gene expression profiling of placentae from women with obesity and obstructive sleep apnoea

Autor: Emma C. Johns, Daniel L. Halligan, Triin Tammsalu, Elizabeth A. Hill, Renata L. Riha, Fiona C. Denison, Rebecca M. Reynolds

Publikováno v: Johnson, E C, Halligan, D, Tammsalu, T, Hill, E A, Riha, R L, Denison, F C & Reynolds, R M 2022, ' Gene expression profiling of placentae from women with obesity and obstructive sleep apnoea ', Placenta . https://doi.org/10.1016/j.placenta.2022.03.001

Introduction: Obstructive sleep apnoea (OSA), a condition characterised by intermittent hypoxia and reoxygenation during sleep, is associated with an increased risk of adverse pregnancy outcomes including gestational diabetes and hypertensive disorde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4864c9c08f21eca173c4d1ef973a97
https://pubmed.ncbi.nlm.nih.gov/35278842

Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase

Autor: Kaspar Reier, Aivar Liiv, Jamie H. D. Cate, Arto Pulk, Triin Tammsalu, Jaanus Remme, Lauri Peil, Silva Lilleorg

Publikováno v: Biochimie. 156:169-180

Ribosomes consist of many small proteins and few large RNA molecules. Both components are necessary for ribosome functioning during translation. According to widely accepted view, bacterial ribosomes contain always the same complement of ribosomal pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c78021d80fac188e3bec37360a48a58
https://doi.org/10.1016/j.biochi.2018.10.013

Controlling and co-ordinating chitinase secretion in a

Autor: Marília de Assis Alcoforado, Costa, Richard A, Owen, Triin, Tammsalu, Grant, Buchanan, Tracy, Palmer, Frank, Sargent

Publikováno v: Microbiology (Reading, England). 165(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4242ab5a096e7d9a9525b20e7f0b5cdc
https://pubmed.ncbi.nlm.nih.gov/31526448

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

Autor: Triin Tammsalu, Andrea Pawellek, Tony Ly, Ronald T. Hay, Lewis J King, Helmi Kreinin, Angus I. Lamond, Ursula Ryder, Richard C. Hartley

Publikováno v: Pawellek, A, Ryder, U, Tammsalu, T, King, L J, Kreinin, H, Ly, T, Hay, R T, Hartley, R C & Lamond, A I 2017, ' Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP ', eLIFE, vol. 6, e27402 . https://doi.org/10.7554/eLife.27402
eLife, Vol 6 (2017)
eLife

Here, we identify the plant biflavanoid hinokiflavone as an inhibitor of splicingin vitroand modulater of alternative splicing in multiple human cell lines. Hinokiflavone inhibits splicingin vitroby blocking one or more early steps of spliceosome ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58487e17f9a762684ea6b26d35b672
https://hdl.handle.net/20.500.11820/95d6ff0f-74fc-4b16-9f9c-e6a14271f8d9