Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas.

Autor: Peruzzi P; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Dominas C; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA., Fell G; Department of Data Science, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA., Bernstock JD; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Blitz S; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Mazzetti D; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Zdioruk M; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Dawood HY; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Triggs DV; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Ahn SW; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA., Bhagavatula SK; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA., Davidson SM; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08540, USA., Tatarova Z; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA., Pannell M; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Truman K; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Ball A; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Gold MP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Pister V; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fraenkel E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Chiocca EA; Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA., Ligon KL; Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA., Wen PY; Division of Neuro-Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA., Jonas O; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Sep 06; Vol. 15 (712), pp. eadi0069. Date of Electronic Publication: 2023 Sep 06.