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Akademický článek

Photobinding of Triflusal to Human Serum Albumin Investigated by Fluorescence, Proteomic Analysis, and Computational Studies

Autor: Oscar Molins-Molina, Raúl Pérez-Ruiz, Emilio Lence, Concepción González-Bello, Miguel A. Miranda, M. Consuelo Jiménez

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Triflusal is a platelet antiaggregant employed for the treatment and prevention of thromboembolic diseases. After administration, it is biotransformed into its active metabolite, the 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). We present here an i

Externí odkaz: https://doaj.org/article/5d3748bb3f2346468cdea3ff8f701ab4

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Akademický článek

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Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity

Autor: Georgina Fuertes Ferre, Vanesa Alonso-Ventura, Jose Antonio Casasnovas Lenguas, Javier Jimeno Sánchez, José Gabriel Galache Osuna, Eva María Andrés Esteban, José A. Diarte de Miguel, Jose Luis Cubero Saldaña, Jose Antonio Linares Vicente, Maria Rosario Ortas Nadal, Ainhoa Pérez Guerrero

Publikováno v: Cardiology. 146:426-430

Background: Acetylsalicylic acid hypersensitivity (ASAH) limits therapeutic options in patients with acute coronary syndrome (ACS), who benefit from dual antiplatelet therapy (DAPT), especially when undergoing stent implantation. Our aim was to evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f68c29d0cc7ab756ac04c6d8c1bb7239
https://doi.org/10.1159/000514414

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Application of an LC-MS/MS Method to a Urinary Excretion Study of Triflusal and its Main Metabolite 2-hydroxy-4-trifluoromethyl Benzoic Acid in Human Urine

Autor: Jin-Wen Wang, Qi-Yan Guo, Jie Ge, Ai-Dong Wen

Publikováno v: Current Pharmaceutical Analysis. 16:328-334

Objective: A validated liquid chromatography-tandem mass spectrometry method (LCMS/ MS) was established to simultaneously determine the concentration of triflusal and its main metabolite 2-hydroxy-4-trifluoromethyl benzoic acid(HTB) in human urine. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b5b4b4200f4b7a559a520e92012ee52
https://doi.org/10.2174/1573412914666181105125225

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Akademický článek

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease

Autor: M. Coma, L. Serenó, B. Da Rocha-Souto, T.C. Scotton, J. España, M.B. Sánchez, M. Rodríguez, J. Agulló, C. Guardia-Laguarta, M. Garcia-Alloza, L.A. Borrelli, J. Clarimón, A. Lleó, B.J. Bacskai, C.A. Saura, B.T. Hyman, T. Gómez-Isla

Publikováno v: Neurobiology of Disease, Vol 38, Iss 3, Pp 482-491 (2010)

Inflammation has been associated with the two classic lesions in the Alzheimer's (AD) brain, amyloid deposits and neurofibrillary tangles. Recent data suggest that Triflusal, a compound with potent anti-inflammatory effects in the central nervous sys

Externí odkaz: https://doaj.org/article/5b3c6cc2f7e6413a8cfd81bd1ab8f42f

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Kniha

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Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping

Publikováno v: Journal of Stroke, Vol 19, Iss 3, Pp 356-364 (2017)
Journal of Stroke

Background and purpose To compare the efficacy and safety of antiplatelet agents for the secondary prevention of ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms. Methods This study was a prospective, multicenter, randomized, par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4857a64ecf4fce43e8d04842ac7569
http://www.j-stroke.org/upload/pdf/jos-2017-01249.pdf

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Photobinding of triflusal to human serum albumin investigated by fluorescence, proteomic analysis, and computational studies

Autor: Miguel A. Miranda, Oscar Molins-Molina, Raúl Pérez-Ruiz, Emilio Lence, Concepción González-Bello, M. Consuelo Jiménez

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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Frontiers in Pharmacology
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Digital.CSIC. Repositorio Institucional del CSIC
Frontiers in Pharmacology, Vol 10 (2019)

[EN] Triflusal is a platelet antiaggregant employed for the treatment and prevention of thromboembolic diseases. After administration, it is biotransformed into its active metabolite, the 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). We present here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb343397da4d10599a55ce252cbba45
http://hdl.handle.net/10347/21313

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