Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Trieu-Du Ngo"'
Publikováno v:
Molecules, Vol 17, Iss 4, Pp 4560-4582 (2012)
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, a support vector machine model was performed on a series of 73 analogues to classify BCP derivativ
Externí odkaz:
https://doaj.org/article/09be57f9b546440dbabb9a588f9ac60b
Autor:
Minh-Tri Le, Dieu-Thuong Thi Trinh, Trieu-Du Ngo, Viet-Khoa Tran-Nguyen, Dac-Nhan Nguyen, Tung Hoang, Hoang-Minh Nguyen, Tran-Giang-Son Do, Tan Thanh Mai, Thanh-Dao Tran, Khac-Minh Thai
Publikováno v:
BioMed Research International.
The human P-glycoprotein (P-gp) and the NorA transporter are the major culprits of multidrug resistance observed in various bacterial strains and cancer cell lines, by extruding drug molecules out of the targeted cells, leading to treatment failures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29a06b6c68b2f00ec2bd51101f1cd28
Autor:
Minh-Tri, Le, Dieu-Thuong Thi, Trinh, Trieu-Du, Ngo, Viet-Khoa, Tran-Nguyen, Dac-Nhan, Nguyen, Tung, Hoang, Hoang-Minh, Nguyen, Tran-Giang-Son, Do, Tan Thanh, Mai, Thanh-Dao, Tran, Khac-Minh, Thai
Publikováno v:
BioMed research international. 2022
The human P-glycoprotein (P-gp) and the NorA transporter are the major culprits of multidrug resistance observed in various bacterial strains and cancer cell lines, by extruding drug molecules out of the targeted cells, leading to treatment failures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a13bb84954d4520b2fc94be8377a988a
https://pubmed.ncbi.nlm.nih.gov/35378788
https://pubmed.ncbi.nlm.nih.gov/35378788
Autor:
Khac-Minh Thai, Thanh-Dao Tran, Ngoc-Vinh Nguyen, Minh-Tri Le, Thien-Hai Nguyen, Thien-Vy Phan, Trieu-Du Ngo
Publikováno v:
Medicinal Chemistry. 11:135-155
NorA is a member of the Major Facilitator Superfamily (MFS) drug efflux pumps that have been shown to mediate antibiotic resistance in Staphylococcus aureus (SA). In this study, QSAR analysis, virtual screening and molecular docking were implemented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b41ec8ad8113cbf9b22c2ae54b86934
https://doi.org/10.2174/1573406410666140902110903
https://doi.org/10.2174/1573406410666140902110903
Publikováno v:
Current Topics in Medicinal Chemistry. 13:1002-1014
The pharmacophore modeling in modern drug research has been applied for both bioactivity profiling and early stage of risk assessment of potential side effects and toxicity due to interactions of drug candidates with antitargets namely P-glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f3c336039d265ef1b5edfa572ef1e1
https://doi.org/10.2174/1568026611313090004
https://doi.org/10.2174/1568026611313090004
Publikováno v:
SAR and QSAR in environmental research. 27(9)
The efflux pumps P-glycoprotein (P-gp) in humans and NorA in Staphylococcus aureus are of great interest for medicinal chemists because of their important roles in multidrug resistance (MDR). The high polyspecificity as well as the unavailability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd9151bb014d0ad94b8579dfe4a24f7
https://pubmed.ncbi.nlm.nih.gov/27667641
https://pubmed.ncbi.nlm.nih.gov/27667641
Autor:
Khac-Minh Thai, Trieu-Du Ngo, Ngoc Chau Tran, Tuong-Ha Do, Thi-Ngoc-Phuong Huynh, Cat-Dong Tran, Thanh-Dao Tran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4555-4560
A total of 30 chalcone analogues was synthesized via a base catalyzed Claisen Schmidt condensation and screened for their in vitro antibacterial activity against Methicillin-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3dc03787d73ccc56fcfd1cf5af85b9
https://doi.org/10.1016/j.bmcl.2012.05.112
https://doi.org/10.1016/j.bmcl.2012.05.112
Publikováno v:
SAR and QSAR in environmental research. 26(2)
P-glycoprotein (P-gp) is an ATP binding cassette (ABC) transporter that helps to protect several certain human organs from xenobiotic exposure. This efflux pump is also responsible for multi-drug resistance (MDR), an issue of the chemotherapy approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be07d7bbab772f400a10345f11deaf86
https://pubmed.ncbi.nlm.nih.gov/25588022
https://pubmed.ncbi.nlm.nih.gov/25588022
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Akademický článek
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