Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Trieu N. Trinh"'
Autor:
Peter J. Cossar, Mohammed K. Abdel-Hamid, Cong Ma, Jennette A. Sakoff, Trieu N. Trinh, Christopher P. Gordon, Peter J. Lewis, Adam McCluskey
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3839-3857 (2017)
Externí odkaz:
https://doaj.org/article/18507ec09c4e43c9ac4c112c6de0fa28
Autor:
Mohammed K. Abdel-Hamid, Christopher P. Gordon, Trieu N. Trinh, Peter J. Lewis, Jennette A. Sakoff, Adam McCluskey, Peter J. Cossar, Cong Ma
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3839-3857 (2017)
ACS Omega
ACS Omega
The NusB–NusE protein–protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription in all bacteria. This PPI is an emerging antibacterial drug target. Pharmacophore-based screeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1977d171c98dbe496ff032bc277b16e1
https://doi.org/10.1021/acsomega.7b00273
https://doi.org/10.1021/acsomega.7b00273
Autor:
Trieu N. Trinh, Adam McCluskey
Publikováno v:
Tetrahedron Letters. 57:3256-3259
The multicomponent reaction of ethyl 3-aminocrotonate ( 1 ), substituted phenylisothiocyanates ( 2a – i ) and acetic anhydride ( 7 ), afforded facile access to a series of substituted 1,3-thiazine-6-phenylimino-5-carboxylates under mild conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::508df0dfe62816f01d68008c99a43554
https://doi.org/10.1016/j.tetlet.2016.06.007
https://doi.org/10.1016/j.tetlet.2016.06.007
Autor:
Jennette A. Sakoff, Eileen A. McLaughlin, Christopher P. Gordon, V. Pye, Peter J. Cossar, Mohammed K. Abdel-Hamid, Ilana R. Bernstein, Adam McCluskey, Trieu N. Trinh
Publikováno v:
Organic & Biomolecular Chemistry. 14:6304-6315
A series of quinolone-2-(1H)-ones derived from the Ugi-Knoevenagel three- and four-component reaction were prepared exhibiting low micromolar cytotoxicity against a panel of eight human cancer cell lines known to possess the Hedgehog Signalling Pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c06cc240793fb869da3facbd392f374
https://doi.org/10.1039/c6ob00606j
https://doi.org/10.1039/c6ob00606j
Autor:
Eileen A. McLaughlin, Adam McCluskey, Ilana R. Bernstein, Trieu N. Trinh, Christopher P. Gordon, V. Pye, Kate A. Redgrove
Publikováno v:
Organicbiomolecular chemistry. 15(14)
Leveraging our quinolone-1-(2H)-one based Hedgehog signalling pathway (HSP) inhibitors we have developed two new classes of HSP inhibitors based on: L-tryptophan and benzo[1,3]dioxol-5-ylmethyl-[2-(1H-indol-3-yl)-ethyl]-amine. Synthesis of focused co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091b303b311f548a827f0a1305f40d24
https://pubmed.ncbi.nlm.nih.gov/28318003
https://pubmed.ncbi.nlm.nih.gov/28318003
Autor:
Trieu N. Trinh, Adam McCluskey
Publikováno v:
Tetrahedron Letters. 59:3155-3156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cb5f6aabd9d7389d0dd099937e780d
https://doi.org/10.1016/j.tetlet.2018.07.018
https://doi.org/10.1016/j.tetlet.2018.07.018
Publikováno v:
Med. Chem. Commun.. 5:117-133
The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation of developing tissues and ensuring attainment of the correct size, posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a53901c86221806b81ff85951ec5f1
https://doi.org/10.1039/c3md00334e
https://doi.org/10.1039/c3md00334e
Autor:
Adam McCluskey, Trieu N. Trinh
Publikováno v:
ChemInform. 47
The multicomponent reaction of ethyl 3-aminocrotonate ( 1 ), substituted phenylisothiocyanates ( 2a – i ) and acetic anhydride ( 7 ), afforded facile access to a series of substituted 1,3-thiazine-6-phenylimino-5-carboxylates under mild conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88307b077c834a7c041d4dca2b0c3c2c
https://doi.org/10.1002/chin.201646187
https://doi.org/10.1002/chin.201646187
Autor:
Trieu N. Trinh, David G. Harman, Lacey Hizartzidis, Christopher P. Gordon, Andrew J. S. Lin, Adam McCluskey
Publikováno v:
Organicbiomolecular chemistry. 12(47)
Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N(+)F(-) and the immobilised t-butyl based palladium catalyst CatCart™ FC1032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc3d28528a1d0abe0d40565f0f2586
https://pubmed.ncbi.nlm.nih.gov/25333944
https://pubmed.ncbi.nlm.nih.gov/25333944