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The genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.

Autor: Santarsieri A; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; University of Cambridge, Wellcome-Medical Research Council Stem Cell Institute, Cambridge, UK; Faculty of Health, Medicine, and Social Care, Anglia Ruskin University, Cambridge, UK., Mitchell E; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; University of Cambridge, Wellcome-Medical Research Council Stem Cell Institute, Cambridge, UK., Pham MH; Wellcome Sanger Institute, Cambridge, UK., Sanghvi R; Wellcome Sanger Institute, Cambridge, UK., Jablonski J; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany; German Hodgkin Study Group, Cologne, Germany., Lee-Six H; Wellcome Sanger Institute, Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK., Sturgess K; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brice P; APHP Hôpital Saint-Louis, Hemato-Oncologie, Paris, France., Menne TF; Department of Haematology, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Osborne W; Department of Haematology, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK; Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK., Creasey T; Department of Haematology, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK., Ardeshna KM; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Baxter J; Cambridge Blood and Stem Cell Biobank, NHS-BT Cambridge Centre, Cambridge, UK., Behan S; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bhuller K; Department of Haematology, University Hospitals of Leicester NHS Trust, Leicester, UK., Booth S; Department of Haematology, Royal Berkshire Hospital, Reading, UK., Chavda ND; Department of Haematology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Collins GP; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK., Culligan DJ; Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, UK., Cwynarski K; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Davies A; Department of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Downing A; Department of Haematology, Velindre Cancer Centre, Cardiff, UK., Dutton D; Department of Haematology, Great Western Hospitals NHS Foundation Trust, Swindon, UK., Furtado M; Department of Haematology, Royal Cornwall Hospital, Truro, UK., Gallop-Evans E; Department of Haematology, Velindre Cancer Centre, Cardiff, UK., Hodson A; Department of Haematology, Ipswich Hospital NHS Trust, Ipswich, UK., Hopkins D; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Hsu H; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, UK., Iyengar S; Department of Haematology, Royal Marsden Hospital, London, UK., Jones SG; Department of Haematology, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, UK., Karanth M; Department of Haematology, West Suffolk NHS Foundation Trust, Bury St Edmunds, UK., Linton KM; Department of Haematology, University of Manchester and the Christie Hospital, Division of Cancer Sciences, Manchester, UK., Lomas OC; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK., Martinez-Calle N; Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK., Mathur A; Department of Haematology, Aberdeen Royal Infirmary, Aberdeen, UK., McKay P; Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK., Nagumantry SK; Department of Haematology, Peterborough City Hospital, Peterborough, UK., Phillips EH; Department of Haematology, University of Manchester and the Christie Hospital, Division of Cancer Sciences, Manchester, UK., Phillips N; Department of Haematology, Royal Stoke University Hospital, Stoke-on-Trent, UK., Rudge JF; Bullard Laboratories, Department of Earth Sciences, University of Cambridge, Cambridge, UK., Shah NK; Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK., Stafford G; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Sternberg A; Department of Haematology, Great Western Hospitals NHS Foundation Trust, Swindon, UK., Trickey R; Department of Haematology, Velindre Cancer Centre, Cardiff, UK., Uttenthal BJ; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wetherall N; Department of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Zhang XY; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK., McMillan AK; Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK., Coleman N; Department of Pathology, University of Cambridge, Cambridge, UK., Stratton MR; Wellcome Sanger Institute, Cambridge, UK., Laurenti E; University of Cambridge, Wellcome-Medical Research Council Stem Cell Institute, Cambridge, UK., Borchmann P; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany; German Hodgkin Study Group, Cologne, Germany., Borchmann S; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany; German Hodgkin Study Group, Cologne, Germany., Campbell PJ; Wellcome Sanger Institute, Cambridge, UK., Rahbari R; Wellcome Sanger Institute, Cambridge, UK. Electronic address: rr11@sanger.ac.uk., Follows GA; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Faculty of Health, Medicine, and Social Care, Anglia Ruskin University, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK. Electronic address: gf246@cam.ac.uk.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2024 Dec 11. Date of Electronic Publication: 2024 Dec 11.