An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion

Autor: Tricia T Nguyen, Gia K Voeltz

Publikováno v: eLife, Vol 11 (2022)

Mitochondria are dynamic organelles that undergo cycles of fission and fusion at a unified platform defined by endoplasmic reticulum (ER)-mitochondria membrane contact sites (MCSs). These MCSs or nodes co-localize fission and fusion machinery. We set

Externí odkaz: https://doaj.org/article/1baf520fb89f4385adda0fd2c4b79203

Adjuvant Screen Identifies Synthetic DNA-Encoding Flt3L and CD80 Immunotherapeutics as Candidates for Enhancing Anti-tumor T Cell Responses

Autor: Jian Yan, Tricia T Nguyen, Charles C. Reed, Trevor R.F. Smith, Amy Haseley Thorne, Kirsten N Malo, Emma L Masteller, Neil Cooch, Ashley J Wong, Laurent Humeau, Kate E. Broderick

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

Overcoming tolerance to tumor-associated antigens remains a hurdle for cancer vaccine-based immunotherapy. A strategy to enhance the anti-tumor immune response is the inclusion of adjuvants to cancer vaccine protocols. In this report, we generated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76a09984ed0fb09fbacecd3e9543f64
https://www.frontiersin.org/article/10.3389/fimmu.2020.00327/full

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Autor: Bruce J. Tromberg, Seong M. Kim, Robert Edwards, Stephen Hanessian, Ryan J. McMonigle, Garret Guenther, Aimee L. Edinger, Tricia T. Nguyen, Eric O. Potma, Brendan T. Finicle, Yanling Zhang, Bin Chen, Tiffany M. Nguyen, Jue Hou, Atsuo T. Sasaki, Archna Ravi, Satoshi Kofuji, Mari Kono, Lois S. Weisman, Alison N. McCracken, Saurabh G. Roy, Manuel U. Ramirez, Timothy Wiher, Elizabeth Selwan

Publikováno v: Kim, Seong M; Roy, Saurabh G; Chen, Bin; Nguyen, Tiffany M; McMonigle, Ryan J; McCracken, Alison N; et al.(2016). Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. Journal of Clinical Investigation, 126(11), 4088-4102. doi: 10.1172/jci87148. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6zh0q267

Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd0ed68029bf8a65f6d0ff97e053648
https://doi.org/10.1172/jci87148

Exercise-based cardiac rehabilitation in heart transplant recipients

Autor: Lindsey Anderson, Christian H Dall, Tricia T Nguyen, Laura Burgess, Rod S Taylor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2254ab6536775cc9d0c84bf07fc1468
https://doi.org/10.1002/14651858.cd012264

Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors.

Autor: Kintu TM; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Katengeke V; Office of Research Administration, Mbarara University of Science and Technology, Mbarara, Uganda., Kamoga R; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Nguyen T; California University of Science and Medicine, Colton, California, United States of America., Najjuma JN; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda., Kitya D; Department of Neurosurgery, Mbarara University of Science and Technology, Mbarara, Uganda., Wakida EK; Office of Research Administration, Mbarara University of Science and Technology, Mbarara, Uganda.; Department of Medical Education, California University of Science and Medicine, Colton, California, United States of America., Obua C; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.; Office of Research Administration, Mbarara University of Science and Technology, Mbarara, Uganda., Rukundo GZ; Department of Psychiatry, Mbarara University of Science and Technology, Mbarara, Uganda.

Publikováno v: PLOS global public health [PLOS Glob Public Health] 2023 Feb 06; Vol. 3 (2), pp. e0001459. Date of Electronic Publication: 2023 Feb 06 (Print Publication: 2023).