Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tricia Protack"'
Autor:
Zeyu Lin, Joseph Cantone, Hao Lu, Beata Nowicka-Sans, Tricia Protack, Tian Yuan, Hong Yang, Zheng Liu, Dieter Drexler, Alicia Regueiro-Ren, Nicholas A Meanwell, Mark Cockett, Mark Krystal, Max Lataillade, Ira B Dicker
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005990 (2016)
HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second g
Externí odkaz:
https://doaj.org/article/a90b160f045e49bcad42a4f0b6eb0ad7
Autor:
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J. Swidorski, Zheng Liu, Brian L. Venables, Ny Sin, Richard A. Hartz, Tricia Protack, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh-Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Hyunsoo Park, Amy Sarjeant, Yulia Benitex, Sandhya Rahematpura, Dawn Parker, Thomas Phillips, Roy Haskell, Susan Jenkins, Kenneth S. Santone, Mark Cockett, Umesh Hanumegowda, Ira Dicker, Nicholas A. Meanwell, Mark Krystal
Publikováno v:
Journal of medicinal chemistry. 65(18)
GSK3640254 is an HIV-1 maturation inhibitor (MI) that exhibits significantly improved antiviral activity toward a range of clinically relevant polymorphic variants with reduced sensitivity toward the second-generation MI GSK3532795 (BMS-955176). The
Autor:
Tricia Protack, Michael A. Walker, Guo Li, David R. Langley, B. Narasimhulu Naidu, Nicholas A. Meanwell, George L. Trainor, Alicia Ng, Susan Jenkins, Mark Krystal, Zeyu Lin, Samuel Gerritz, Christopher Cianci, Hal A. Lewis, Kevin Kish, Javed Khan, Prasanna Sivaprakasam, Annapurna Pendri, Ira B. Dicker, Linda Discotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2620-2637
The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the success of HAART, new drugs with novel mechanisms are needed to combat viral resistance, impro
Autor:
Tricia Protack, Sing-Yuen Sit, Dieter M. Drexler, Alicia Regueiro-Ren, Mark I. Cockett, Yan Chen, Jerry Jeffrey, Nicholas A. Meanwell, Joseph L. Cantone, Ira B. Dicker, Martin Gartland, Mark Krystal, Zeyu Lin, Brian McAuliffe
Publikováno v:
Antimicrobial Agents and Chemotherapy
HIV-1 maturation inhibitors (MIs) offer a novel mechanism of action and potential for use in HIV-1 treatment. Prior MIs displayed clinical efficacy but were associated with the emergence of resistance and some gastrointestinal tolerability events. Tr
Autor:
Anuradha Gupta, Ira B. Dicker, Mark Krystal, Tricia Protack, Jacob Swidorski, Yoganand Shanmugam, Susan Jenkins, Alicia Ng, Umesh Hanumegowda, Nicholas A. Meanwell, Dawn D. Parker, Alicia Regueiro-Ren, Brett R. Beno
Publikováno v:
Bioorganicmedicinal chemistry letters. 36
GSK3532795 (formerly BMS-955176) is a second-generation HIV-1 maturation inhibitor that has shown broad spectrum antiviral activity and preclinical PK predictive of once-daily dosing in humans. Although efficacy was confirmed in clinical trials, the
Autor:
B. Narasimhulu Naidu, Dawn D. Parker, Helen Higley, Tricia Protack, Susan Jenkins, Manoj Patel, Zeyu Lin, Nicholas A. Meanwell, Brian Terry, Ira B. Dicker, Arvind Mathur, Chiradeep Panja, Michael A. Walker, Mark Krystal, Richard Rampulla
Publikováno v:
Bioorganicmedicinal chemistry. 28(13)
The design, synthesis and structure-activity relationships associated with a series of bridged tricyclic pyrimidinone carboxamides as potent inhibitors of HIV-1 integrase strand transfer are described. Structural modifications to these molecules were
Autor:
Alicia Regueiro-Ren, Jacob J. Swidorski, Zheng Liu, Yan Chen, Ny Sin, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Juliang Zhu, Beata Nowicka-Sans, Tricia Protack, Zeyu Lin, Brian Terry, Himadri Samanta, Sharon Zhang, Zhufang Li, John Easter, Brett R. Beno, Vinod Arora, Xiaohua S. Huang, Sandhya Rahematpura, Dawn D. Parker, Roy Haskell, Kenneth S. Santone, Mark I. Cockett, Mark Krystal, Nicholas A. Meanwell, Susan Jenkins, Umesh Hanumegowda, Ira B. Dicker
Publikováno v:
Journal of Medicinal Chemistry. 61:7289-7313
Autor:
Max Lataillade, Ira B. Dicker, Monique Nijhuis, Mark Krystal, Petronella Maria van Ham, Zeyu Lin, Tianbo Li, Neelanjana Ray, Carey Hwang, Tricia Protack
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes (1999)
Supplemental Digital Content is Available in the Text.
Background: Protease inhibitor (PI)-resistant HIV-1 isolates with primary substitutions in protease (PR) and secondary substitutions in Gag could potentially exhibit cross-resistance to matu
Background: Protease inhibitor (PI)-resistant HIV-1 isolates with primary substitutions in protease (PR) and secondary substitutions in Gag could potentially exhibit cross-resistance to matu
Autor:
Michael A. Walker, Kevin M. Peese, Volodymyr Gali, Himadri Samanta, Manoj Patel, Ming Zheng, David R. Langley, B. Narasimhulu Naidu, Chen Li, Tricia Protack, Ira B. Dicker, Susan Jenkins, Zeyu Lin, Nicholas A. Meanwell, Brian Terry, Mark Krystal
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(3)
A series of heterocyclic pyrimidinedione-based HIV-1 integrase inhibitors was prepared and screened for activity against purified integrase enzyme and/or viruses modified with the following mutations within integrase: Q148R, Q148H/G140S and N155H. Th
Autor:
Umesh Hanumegowda, Sharon Zhang, Yan Chen, Zheng Liu, Ira B. Dicker, Zhufang Li, Sing-Yuen Sit, Ny Sin, Jacob Swidorski, Brian Terry, Himadri Samanta, Tricia Protack, Brian Lee Venables, Zeyu Lin, Yongnian Sun, Jie Chen, Beata Nowicka-Sans, Alicia Regueiro-Ren, Nicholas A. Meanwell, Matthew D. Healy, Mark Krystal, Mark I. Cockett
Publikováno v:
Antimicrobial Agents and Chemotherapy
BMS-955176 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in early-phase studies, but ∼50% of subjects had viruses with reduced susceptibility