Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tricia L. May-Dracka"'
Autor:
Jane Aldrich, Shelley Allen, Erika Araujo, Joanne Bronson, Amanda Bryant-Friedrich, Shana K. Cyr, Erin F. DiMauro, Carolyn Dzierba, Amanda L. Garner, Gunda I. Georg, Nicole C. Goodwin, Krupanandan Haranahalli, Rong Huang, Katerina Leftheris, Tricia L. May-Dracka, Margaret E. Olson, Maria-Jesus Blanco
Publikováno v:
Journal of Medicinal Chemistry. 66:3651-3655
Autor:
Tricia L. May-Dracka, Fang Gao, Brian T. Hopkins, Xiaoping Hronowski, TeYu Chen, Jayanth V. Chodaparambil, Claire M. Metrick, Mike Cullivan, Istvan Enyedy, Maciej Kaliszczak, Mark W. Kankel, Isaac Marx, Mackenzie A. Michell-Robinson, Param Murugan, P. Rajesh Kumar, Michael Rooney, Eli Schuman, Anindya Sen, Ti Wang, Tao Ye, Emily A. Peterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe055bd69fb8ef7e48f9498480b28a32
https://europepmc.org/articles/PMC9014516/
https://europepmc.org/articles/PMC9014516/
Autor:
Kerri Spilker, K. Michelsen, E.A. Peterson, P.R. Kumar, I.J. Enyedy, Tricia L. May-Dracka, T. Chen, Claire M. Metrick, Jayanth V. Chodaparambil, Paramasivam Murugan, M. Cullivan, Joseph C Santoro
Publikováno v:
Nature Chemical Biology. 16:391-399
Phospholipase D enzymes (PLDs) are ubiquitous phosphodiesterases that produce phosphatidic acid (PA), a key second messenger and biosynthetic building block. Although an orthologous bacterial Streptomyces sp. strain PMF PLD structure was solved two d
Autor:
Alita A. Miller, Sushmita D. Lahiri, Tommasi Ruben A, Janelle Comita-Prevoir, Sarah M. McLeod, Michael Dominic Sacco, Frank Wu, Jeroen C. Verheijen, Adam B. Shapiro, April Chen, Thomas F. Durand-Reville, Jan Antoinette C. Romero, Robert A. Giacobbe, Tricia L. May-Dracka, Nicole M. Carter, John P. O'Donnell, Yu Chen, Wu Xiaoyun, Jing Zhang, John P. Mueller
Publikováno v:
Journal of Medicinal Chemistry
Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases are responsible for a large proportion of the res
Autor:
Joseph P. Lyssikatos, Douglas Marcotte, Christine Lukacs, Mia Rushe, Kevin Little, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Xin Zhili, Tricia L. May-Dracka, Murugan Paramasivam, Thomas A. Patterson, Govinda Bhisetti, Timothy D. McKee, Kateri Atkins, Michael Cullivan, Thomas Hesson, Laura Silvian, Xin E. Sun
Publikováno v:
Protein Science. 26:152-162
Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain
Autor:
Erik C. Hett, Michelle L. Ols, Kejie Li, Elisabeth Vollman, Tricia L. May-Dracka, Tracy J. Jenkins, Paramasivam Murugan, Weike Zeng, Jun Feng, Kate L. Henry, Capacci Andrew George, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Brian Lucas, Christine Loh, Alan Buckler, Thomas Cameron, Peter Juhasz, Brian T. Hopkins, Katelin A. Ennis, John E. Anderson, Mercedes Beyna, Benbo Gao, Debra Kellner, Norm Allaire, Govinda Bhisetti, Ru Wei, Bekim Bajrami
Publikováno v:
Science signaling. 11(541)
Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-κB complexes are
Autor:
Linda C. Burkly, Tricia L. May-Dracka, Jason D. Fontenot, Joe Lyssikatos, Timothy D. McKee, Douglas Marcotte, Laura Silvian, Thomas Hesson, Istvan J. Enyedy, Zhili Xin, Thomas A. Patterson, Margot Brickelmaier, Ping Wu, Mia Rushe, Govinda Bhisetti, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Paramasivam Murugan, Kerri Spilker, Hairuo Peng, Kevin Little
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(10)
Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling
Publikováno v:
Journal of Medicinal Chemistry. 57:10144-10161
To better understand the difficulties surrounding the identification of novel antibacterial compounds from corporate screening collections, physical properties of ∼3200 antibacterial project compounds with whole cell activity against Gram-negative
Autor:
Brian A. Stearns, Alec D. Lebsack, Tricia L. May-Dracka, Stephen M. Canham, Larry E. Overman, Benjamin D. Hafensteiner, Sangkil Nam
Publikováno v:
Tetrahedron, vol 71, iss 37
A unified strategy for enantioselective total synthesis of all stereoisomers of the [2+2] family of quadrigemine alkaloids is reported. In this approach, two enantioselective intramolecular Heck reactions are carried out at the same time on precursor
Publikováno v:
ChemInform. 45
Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes an