Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tricia J. Vos"'
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 42KB, Pharmacokinetic profiles of plasma and OCI-LY19-Luc tumor tissue in mice treated with a single oral dose of MLN0905.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ea954beedbf17637f8537b8fd5aee6
https://doi.org/10.1158/1535-7163.22498068
https://doi.org/10.1158/1535-7163.22498068
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 45KB, MLN0905 yields significant anti-tumor responses in mice bearing subcutaneous OCI LY-19-Luc tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a960e23e2a1bc65fdbb320b77b4fdf
https://doi.org/10.1158/1535-7163.22498062
https://doi.org/10.1158/1535-7163.22498062
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 43KB, Evaluating pHisH3 in OCI LY-19-Luc and OCI LY-10 cells following MLN0905 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2ef5c462c57c2eb53338e8b5d557cd
https://doi.org/10.1158/1535-7163.22498065
https://doi.org/10.1158/1535-7163.22498065
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
Diffuse large B-cell lymphoma (DLBCL) is the most common of the non–Hodgkin lymphomas, accounting for up to 30% of all newly diagnosed lymphoma cases. Current treatment options for this disease are effective, but not always curative; therefore, exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7573dff6ab61ceff7bdea55e63d0cff
https://doi.org/10.1158/1535-7163.c.6535776.v1
https://doi.org/10.1158/1535-7163.c.6535776.v1
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 59KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2306d47b0fbd8ce641522a2fddb308e
https://doi.org/10.1158/1535-7163.22498056.v1
https://doi.org/10.1158/1535-7163.22498056.v1
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 44KB, Evaluating cell viability in DLBCL cell lines following MLN0905 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f5012a162499c8238d4f025e4d3d25
https://doi.org/10.1158/1535-7163.22498053.v1
https://doi.org/10.1158/1535-7163.22498053.v1
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 53KB, MLN0905 yields significant anti-tumor responses in mice bearing subcutaneous OCI LY-10 tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36aed04b7a174d5231696d76eadc1e63
https://doi.org/10.1158/1535-7163.22498059
https://doi.org/10.1158/1535-7163.22498059
Autor:
Marc L. Hyer, Natalie D' Amore, Tricia J. Vos, Mark G. Manfredi, Matt O. Duffey, Youlan Rao, Benjamin S. Amidon, Michelle Tighe Nestor, Denise Driscoll, Ray Liu, Debra Liao, Mark G. Qian, Bradley Stringer, Vaishali Shinde, Kerri Lasky, Judy Quiju Shi
PDF file, 48KB, Plasma and OCI LY-19-Luc tumor pharmacokinetic parameters following a single oral dose of MLN0905 in CB-17 SCID mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ad3ce6e190b2b16c5a8f7acf14d6aa
https://doi.org/10.1158/1535-7163.22498050
https://doi.org/10.1158/1535-7163.22498050
Autor:
Todd B. Sells, Ryan Chau, Jeffrey A. Ecsedy, Rachel E. Gershman, Kara Hoar, Jessica Huck, David A. Janowick, Vivek J. Kadambi, Patrick J. LeRoy, Matthew Stirling, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Suresh K. Balani, Joseph B. Bolen, Mark G. Manfredi, Christopher F. Claiborne
Publikováno v:
ACS Medicinal Chemistry Letters. 6:630-634
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, select
Autor:
Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
Publikováno v:
Journal of Medicinal Chemistry. 54:1836-1846
Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma pat