Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tribhuwan K. Gupta"'
Publikováno v:
Journal of Medicinal Chemistry. 19:40-47
The synthesis for 8-chloro-(S)- and -(R)-10-[(S)- and -(R)-3'-methylethylaminopyrrolidino]-10,11-dihydrodibenzo[b,f]thiepins is presented. The absolute configuration at position 3' of the aminopyrrolidino side chain is known from synthesis and corres
Publikováno v:
Journal of Medicinal Chemistry. 19:1419-1422
For purposes of carrying out structure-activity studies on a series of pure R and S enantiomorphs of various para-substituted N-acetyl-alpha-amino-N-phenylglutarimides, we synthesized the p-acetyl, iodo, cyano, ethyl, and n-butyl analogues. These com
Autor:
Michael C. Gerald, Tribhuwan K. Gupta
Publikováno v:
European Journal of Pharmacology. 41:231-234
The (+)-amphetamine (2.5 mg/kg) increase in pentylenetetrazol seizure was abolished by pretreatment with reserpine, alpha-methyltyrosine methyl ester (alpha-MT), FLA-63 or 6-hydroxydopa. All treatments except reserpine antagonized the increase in sei
Autor:
Tribhuwan K. Gupta, Michael C. Gerald
Publikováno v:
Toxicology and Applied Pharmacology. 37:473-479
The LD50 and median neurotoxic dose (as determined by impairment of rotarod performance) of sodium cyanate (NaOCN) were determined to be 278 and 155 mg/kg, ip, respectively. At doses of 38.75–155 mg/kg, NaOCN increased the susceptibility of mice to
Autor:
Wayne L. Cook, Tribhuwan K. Gupta, Minatelli John Adrian, Donald T. Witiak, Babu R. Vishnuvajjala, Michael C. Gerald
Publikováno v:
Journal of medicinal chemistry. 20(6)
The chiral title compounds 2--11 were assessed for their potential anti-Parkinsonian, antipsychotic, and anticonvulsant properties. The most striking differences in the biological activity of enantiomeric pairs were noted for D-(R)-2-amino-N-(3,4-met
Autor:
W. L. Cook, Tribhuwan K. Gupta, Donald T. Witiak, Michael C. Gerald, Babu R. Vishnuvajjala, J. A. Minatelli
Publikováno v:
Chemischer Informationsdienst. 8
Autor:
Tribhuwan K. Gupta, Michael C. Gerald
Publikováno v:
The Journal of pharmacy and pharmacology. 29(2)
Publikováno v:
Chemischer Informationsdienst. 7
The synthesis for 8-chloro-(S)- and -(R)-10-[(S)- and -(R)-3'-methylethylaminopyrrolidino]-10,11-dihydrodibenzo[b,f]thiepins is presented. The absolute configuration at position 3' of the aminopyrrolidino side chain is known from synthesis and corres
Autor:
Tribhuwan K. Gupta, Michael C. Gerald
Publikováno v:
Psychopharmacology. 55(1)
The amphetamine isomers impair the rotarod performance of rats in a dose-related manner, with (+)-amphetamine approximately four-times as potent as its (-)-isomer. At a rotation speed of 4 rpm, 60 min after i.p. administration, the TD50 values (mg/kg
Publikováno v:
Experientia. 33(1)
Differences in neuroleptic activity were observed between the diastereoisomers of a dihydrodibenzothiepin derivative, while no potency differences were seen between their respective enantiomorphs.