Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Triantafyllos Stylianopoulos"'
Autor:
Chrysovalantis Voutouri, Demetris Englezos, Constantinos Zamboglou, Iosif Strouthos, Giorgos Papanastasiou, Triantafyllos Stylianopoulos
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Background In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may not benefit, leading to the varied effic
Externí odkaz:
https://doaj.org/article/b578150787dd467593a51d5b965c93cb
Autor:
John D. Martin, Fotios Mpekris, Vikash P. Chauhan, Margaret R. Martin, Megan E. Walsh, Matthew D. Stuber, Donald M. McDonald, Fan Yuan, Triantafyllos Stylianopoulos, Rakesh K. Jain
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
To have the desired therapeutic effect, nanomedicines and macromolecular medications must move from the site of injection to the site of action, without having adverse effects. Transvascular transport is a critical step of this navigation, as exempli
Externí odkaz:
https://doaj.org/article/9ed9860ace2642fc8ed6cfa691fca649
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101944- (2024)
In the pursuit of advancing cancer therapy, this study explores the predictive power of machine learning in analyzing tumor characteristics, specifically focusing on the effects of tumor stiffness and perfusion (i.e., blood flow) on treatment efficac
Externí odkaz:
https://doaj.org/article/d10010e0cf5045aabc75ba887fbe7949
Autor:
Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Christina Michael, Antonia Papoui, Triantafyllos Stylianopoulos
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 51, Iss , Pp 100990- (2024)
The lack of properly perfused blood vessels within tumors can significantly hinder the distribution of drugs, leading to reduced treatment effectiveness and having a negative impact on the quality of life of patients with cancer. This problem is part
Externí odkaz:
https://doaj.org/article/6efbf96b684c4c089a20698babfabed6
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 011501-011501-18 (2024)
Within the complex tumor microenvironment, cells experience mechanical cues—such as extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, and fluid shear stress—that significantly impact cancer cell behavior
Externí odkaz:
https://doaj.org/article/f25b9344b9d14a579dfd578cd6f48ce7
Autor:
Elena D. Christofidou, Marios Tomazou, Chrysovalantis Voutouri, Christina Michael, Triantafyllos Stylianopoulos, George M. Spyrou, Katerina Strati
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113859- (2024)
Summary: Oct4 is a pioneer transcription factor regulating pluripotency. However, it is not well known whether Oct4 has an impact on epidermal cells. We generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify
Externí odkaz:
https://doaj.org/article/8959792a97b9420ba70536be135f363b
Autor:
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Lance L Munn, Rakesh K Jain, Triantafyllos Stylianopoulos
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301780 (2024)
Critical illness, such as severe COVID-19, is heterogenous in presentation and treatment response. However, it remains possible that clinical course may be influenced by dynamic and/or random events such that similar patients subject to similar injur
Externí odkaz:
https://doaj.org/article/14299f1c215547adae64ad9a199da9f3
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011740 (2023)
Intratumoral injection of immunotherapy aims to maximize its activity within the tumor. However, cytokines are cleared via tumor vessels and escape from the tumor periphery into the host-tissue, reducing efficacy and causing toxicity. Thus, understan
Externí odkaz:
https://doaj.org/article/f783ee49e3834549b243a0f674b40de1
Autor:
Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch. Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Nanotherapy has potential utility in cancer, particularly in targeted delivery of therapeutics. Here the authors demonstrate delivery of tranilast loaded micelles to improve the reprogramming of cancer associated fibroblasts and monitor tumour stiffn
Externí odkaz:
https://doaj.org/article/3c64ee818afc4f9289c24c359d768726
Autor:
Pampina Pilavaki, Myrofora Panagi, Samia Arifi, Robin L. Jones, Triantafyllos Stylianopoulos, Anastasia Constantinidou
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Sarcomas comprise a heterogenous group of malignancies, of more than 100 different entities, arising from mesenchymal tissue, and accounting for 1% of adult malignancies. Surgery, radiotherapy and systemic therapy constitute the therapeutic armamenta
Externí odkaz:
https://doaj.org/article/597be88653fb4762bcd142788d6d18e7