Zobrazeno 1 - 10
of 5 797
pro vyhledávání: '"Trial design"'
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample
Externí odkaz:
https://doaj.org/article/665fb45aa28a4e7f8cf22244c7b7e038
Publikováno v:
Journal of Asthma and Allergy, Vol Volume 17, Pp 801-811 (2024)
Craig LaForce,1 Frank C Albers,2 Mark Cooper,3 Anna Danilewicz,4 Lynn Dunsire,3 Robert Rees,4 Christy Cappelletti5 1North Carolina Clinical Research, Chapel Hill, NC, USA; 2Avillion, Northbrook, IL, USA; 3BioPharmaceuticals Research and Development,
Externí odkaz:
https://doaj.org/article/f3a1870b43c34835acf51dbcd7fac7bc
Autor:
Melissa Pyle, Lucy Loftus, Richard Emsley, Daniel Freeman, Steven Gillard, Andrew Gumley, Justyna Sierpatowska, Lisa Wood, Rory C. O’Connor, Paul Pfeiffer, Sharon Anne Simpson, Nicole Cockayne, Gemma Shields, Ariane Beckley, Helen Beckwith, Maria Filippidou, Callum Glen, Stephanie Allan, Raj Hazzard, Eleanor Longden, Heather Peel, Mark Larsen, Sandra Bucci, Anthony P. Morrison
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background People with serious mental health problems (SMHP) are more likely to be admitted to psychiatric hospital following contact with crisis services. Admissions can have significant personal costs, be traumatic and are the most expensi
Externí odkaz:
https://doaj.org/article/d8f8a6b657044f61bf7c2cdd511ad029
Autor:
Emily Alger, Mary Van Zyl, Olalekan Lee Aiyegbusi, Dave Chuter, Lizzie Dean, Anna Minchom, Christina Yap
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background In light of the FDA’s Project Optimus initiative, there is fresh interest in leveraging Patient-reported Outcome (PRO) data to enhance the assessment of tolerability for investigational therapies within early phase dose-finding
Externí odkaz:
https://doaj.org/article/a5cb45ec14b9497e9b1481114ed722e1
Publikováno v:
Transplant International, Vol 37 (2024)
Based on promising results obtained in primate models, pioneers in the US have now started to explore the new frontier of genetically-edited pig-to-human transplantation. The recent transition of xenotransplantation into clinical medicine has include
Externí odkaz:
https://doaj.org/article/5b94ca76eb474850a533f6f3c2079361
Autor:
Vignan Yogendrakumar, Anna H. Balabanski, Hannah Johns, Leonid Churilov, Nicola K. Parsons, James Beharry, Louise Weir, Nawaf Yassi, Henry Zhao, Alex Warwick, Skye Coote, Francesca Langenberg, Leigh Branagan, Wasseem Siddiqi, Andrew Bivard, Bruce C. V. Campbell, Geoffrey A. Donnan, Stephen M. Davis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Mobile stroke units have been shown to deliver faster patient care and improve clinical outcomes. However, costs associated with staffing limit their use to densely populated cities. Using the Melbourne mobile stroke unit, we aim to evalua
Externí odkaz:
https://doaj.org/article/40ce316dacf14ec9b7426da63e6b4e18
Autor:
John B. Connolly, Austin Burt, George Christophides, Abdoulaye Diabate, Tibebu Habtewold, Penelope A. Hancock, Anthony A. James, Jonathan K. Kayondo, Dickson Wilson Lwetoijera, Alphaxard Manjurano, Andrew R. McKemey, Michael R. Santos, Nikolai Windbichler, Filippo Randazzo
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Sustainable reductions in African malaria transmission require innovative tools for mosquito control. One proposal involves the use of low-threshold gene drive in Anopheles vector species, where a ‘causal pathway’ would be initiated by (
Externí odkaz:
https://doaj.org/article/b6a7d6d5b26e4dd49ad7b5d50b906a08
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Malaria is a potentially life-threatening disease caused by Plasmodium protozoa transmitted by infected Anopheles mosquitoes. Controlled human malaria infection (CHMI) trials are used to assess the efficacy of interventions for ma
Externí odkaz:
https://doaj.org/article/9568b190ea4f404da1c2af8f5f3143af
Autor:
Skerdi Haviari, France Mentré
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-16 (2024)
Background In some medical indications, numerous interventions have a weak presumption of efficacy, but a good track record or presumption of safety. This makes it feasible to evaluate them simultaneously. This study evaluates a pragmatic fractional
Externí odkaz:
https://doaj.org/article/5759292c1f6b4b14acfc02476cef9909
Autor:
Sibyl Anthierens
Publikováno v:
European Journal of General Practice, Vol 30, Iss 1 (2024)
Background As researchers in primary care, we want to drive change in practice and conduct research that sparks meaningful transformation. These changes can only happen if our research work resonates in a meaningful way with the people who they are d
Externí odkaz:
https://doaj.org/article/6ca5b1da088045d796db9f4591f44dc8