Intermittent exposure of cultured endothelial cells to physiologically relevant fructose concentrations has a profound impact on nitric oxide production and bioenergetics.

Autor: Maria Luisa Fiorello, Andrew T Treweeke, David P Macfarlane, Ian L Megson

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0267675 (2022)

Hyperglycaemia is known to induce endothelial dysfunction and changes in metabolic function, which could be implicated in diabetes-induced cardiovascular disease. To date, however, little is known about the impact of physiologically relevant concentr

Externí odkaz: https://doaj.org/article/bedbab2bdcaf47969a7032a63266e13e

Intermittent exposure of cultured endothelial cells to physiologically relevant fructose concentrations has a profound impact on nitric oxide production and bioenergetics.

Autor: Fiorello, Maria Luisa¹ (AUTHOR), Treweeke, Andrew T.¹ (AUTHOR), Macfarlane, David P.² (AUTHOR), Megson, Ian L.¹ (AUTHOR) ian.megson@uhi.ac.uk

Publikováno v: PLoS ONE. 5/13/2022, Vol. 17 Issue 5, p1-16. 16p.

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Autor: Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston

Publikováno v: Sandilands, E A, Rees, J MB, Raja, K, Dhaun, N, Morrison, E E, Hickson, K, Wraight, J, Gray, T, Briody, L, Cameron, S, Thompson, A P, Johnston, N R, Uren, N, Goddard, J, Treweeke, A, Rushworth, G, Webb, D J, Bateman, N, Norrie, J, Megson, I & Eddleston, M 2022, ' Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy-A Failure of Academic Clinical Science ', Clinical pharmacology and therapeutics . https://doi.org/10.1002/cpt.2541

Contrast-induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)-acetylcysteine (NAC) to reduce CIN led to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf68dc214969b61a07ee0f99e8a36c71
https://doi.org/10.1002/cpt.2541

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Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System

Autor: AT Treweeke, Ian L. Megson, Paul A. Cahill, Sandra MacRury, Antonia L. Pritchard, Jacob Roberts, Nicole Brace, Adriano G. Rossi, Jun Wei

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 7 (2021)
Roberts, J, Pritchard, A L, Treweeke, A T, Rossi, A G, Brace, N, Cahill, P, Macrury, S M, Wei, J & Megson, I L 2021, ' Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System ', Frontiers in Cardiovascular Medicine, vol. 7 . https://doi.org/10.3389/fcvm.2020.629933
Frontiers in Cardiovascular Medicine

Meta-analyses have indicated that individuals with type 1 or type 2 diabetes are at increased risk of suffering a severe form of COVID-19 and have a higher mortality rate than the non-diabetic population. Patients with diabetes have chronic, low-leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852b0102b0de1a0c42a0de52dcef048e
https://www.frontiersin.org/articles/10.3389/fcvm.2020.629933/full