Zobrazeno 1 - 10
of 570
pro vyhledávání: '"Trevor W. Hambley"'
Autor:
Christopher J. Burns, Leslie D. Field, Trevor W. Hambley, Thomas Lin, Damon D. Ridley, Peter Turner, Matthew P. Wilkinson
Publikováno v:
ARKIVOC, Vol 2001, Iss 7, Pp 157-165 (2001)
Externí odkaz:
https://doaj.org/article/045783f4ffcf4369b0987a92f9c97079
Autor:
Trevor W. Hambley
Publikováno v:
Targeted Drug Delivery. :271-297
Autor:
Trevor W. Hambley, Ian D. Rae
Publikováno v:
Historical Records of Australian Science. 33:180-190
Hans Freeman was born in Germany and arrived in Australia with his parents in 1938. A brilliant student at the University of Sydney, he spent a seminal year at the California Institute of Technology before joining the staff at Sydney and initiating r
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0217712 (2019)
Glycoconjugation to target the Warburg effect provides the potential to enhance selective uptake of anticancer or imaging agents by cancer cells. A Warburg effect targeting group, rationally designed to facilitate uptake by glucose transporters and p
Externí odkaz:
https://doaj.org/article/0fd7842f5b4944e2b527878aa3f49301
Autor:
Anna K. Renfrew, David J. Paterson, Catherine K. J. Chen, Trevor W. Hambley, Michela I. Simone, Alexandra Glenister
Publikováno v:
Journal of Medicinal Chemistry. 64:2678-2690
A glucose-based vector for targeting cancer cells conjugated to a tris(methylpyridyl)amine (tpa) ligand to generate targeted chaperone and caging complexes for active anticancer agents is described. The ligand, tpa(CONHPEGglucose)1, inhibits hexokina
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 26:217-233
1- and 1,5-Aminoalkylamine substituted anthraquinones (AAQs, 1C3 and 1,5C3) were peptide coupled to 1-, 2-, and 3-pyrrole lexitropsins to generate compounds that incorporated both DNA minor groove and intercalating moieties. The corresponding platinu
Publikováno v:
Dalton Transactions. 50:17945-17952
Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(II) moieties attached were developed with the goal of generating novel DNA binding modes, including the targeting of AT-rich regions in order to have
Publikováno v:
Dalton Transactions. 49:7722-7736
Recent results have confirmed that protection of transplatin from reactions on the path to cancer cells substantially increases their activity, suggesting that such complexes have greater potential than previously thought. In this study we have inves
Publikováno v:
Inorganica Chimica Acta
Recent developments in the design of platinum(IV) pro-drug candidates have demonstrated the importance of the coordination sphere of the complex in determining the resistance to reduction by endogenous reductants and the stability in biologically rel
Autor:
Trevor W. Hambley
Publikováno v:
Journal of Biological Inorganic Chemistry
Precision approaches are rapidly becoming the norm in the treatment of cancer and this is already impacting on the way platinum complexes are used. In this commentary, we will argue that there is the potential for platinum complexes to make a much gr