Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Trevor Van Eeuwen"'
Autor:
Fred E. Fregoso, Malgorzata Boczkowska, Grzegorz Rebowski, Peter J. Carman, Trevor van Eeuwen, Roberto Dominguez
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is poorly understood how cortactin performs these functions.
Externí odkaz:
https://doaj.org/article/883a36d56fea4fb3a7a36c352897a6c3
Autor:
Fred E. Fregoso, Trevor van Eeuwen, Gleb Simanov, Grzegorz Rebowski, Malgorzata Boczkowska, Austin Zimmet, Alexis M. Gautreau, Roberto Dominguez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The Arp2/3 complex inhibitor Arpin controls cell migration by interrupting a feedback loop involving Rac-WAVE-Arp2/3 complex Here, the authors use structural, biochemical, and cellular studies to reveal Arpin’s mechanism of inhibition.
Externí odkaz:
https://doaj.org/article/6a8063234c014575b26daa0160bba64f
Autor:
Jacque L. Faylo, Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. Garcia, Kenji Murakami, David W. Christianson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Substrate channeling can improve biosynthetic efficiency and has been implicated in the reactions of fusicoccadiene synthase. Here, the authors analyze this bifunctional enzyme complex by cryoEM, cross-linking MS and integrative modeling, providing s
Externí odkaz:
https://doaj.org/article/fbb2f4b36b8d4e3eaddd473f28e72330
Autor:
Trevor van Eeuwen, Yoonjung Shim, Hee Jong Kim, Tingting Zhao, Shrabani Basu, Benjamin A. Garcia, Craig D. Kaplan, Jung-Hyun Min, Kenji Murakami
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM struc
Externí odkaz:
https://doaj.org/article/d50d4da2dfcb426987c2cc95413c64ea
Autor:
Stefan Steimle, Trevor van Eeuwen, Yavuz Ozturk, Hee Jong Kim, Merav Braitbard, Nur Selamoglu, Benjamin A. Garcia, Dina Schneidman-Duhovny, Kenji Murakami, Fevzi Daldal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Respiratory chains generate the proton motive force used for ATP synthesis. Cryo-EM structures of functional respiratory CIII2CIV supercomplex and native CIII2 from Rhodobacter capsulatus provide insight into CIII2CIV assembly and respiratory electro
Externí odkaz:
https://doaj.org/article/9384e9b4b26945ae8279e5a9af357d23
Publikováno v:
Biochemistry. 61:2417-2430
Fusicoccadiene synthase from the fungus
Autor:
Toshiya Kozai, Javier Fernandez-Martinez, Trevor van Eeuwen, Paola Gallardo, Larisa E. Kapinos, Adam Mazur, Wenzhu Zhang, Jeremy Tempkin, Radhakrishnan Panatala, Maria Delgado-Izquierdo, Barak Raveh, Andrej Sali, Brian T. Chait, Liesbeth M. Veenhoff, Michael P. Rout, Roderick Y. H. Lim
Nuclear pore complexes (NPCs) mediate nucleocytoplasmic transport of specific macromolecules while impeding the exchange of unsolicited material. However, key aspects of this gating mechanism remain controversial. To address this issue, we determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c479bc774ff96fe6fb7c8fe212cc3b23
https://doi.org/10.1101/2023.03.31.535055
https://doi.org/10.1101/2023.03.31.535055
Autor:
Fred E. Fregoso, Alexis M. Gautreau, Roberto Dominguez, Grzegorz Rebowski, Malgorzata Boczkowska, Trevor van Eeuwen, Gleb Simanov, Austin Zimmet
Positive feedback loops involving signaling and actin assembly factors mediate the formation and remodeling of branched actin networks in processes ranging from cell and organelle motility to mechanosensation. The Arp2/3 complex inhibitor Arpin contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9fa0c9d0f2f81fcd6634f72e44b0ba
https://doi.org/10.1101/2021.10.30.466598
https://doi.org/10.1101/2021.10.30.466598
Autor:
Hee Jong Kim, Jose J. Gorbea Colón, Jacque L. Faylo, Benjamin A. Garcia, Trevor van Eeuwen, Kenji Murakami, David W. Christianson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Fusicoccadiene synthase from Phomopsis amygdali (PaFS) is a unique bifunctional terpenoid synthase that catalyzes the first two steps in the biosynthesis of the diterpene glycoside Fusicoccin A, a mediator of 14-3-3 protein interactions. The prenyltr
Autor:
Yoonjung Shim, Shrabani Basu, Kenji Murakami, Trevor van Eeuwen, Craig D. Kaplan, Tingting Zhao, Benjamin A. Garcia, Jung Hyun Min, Hee Jong Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
The versatile nucleotide excision repair (NER) pathway initiates as the XPC–RAD23B–CETN2 complex first recognizes DNA lesions from the genomic DNA and recruits the general transcription factor complex, TFIIH, for subsequent lesion verification. H