Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Trevor S. Barlowe"'
Autor:
James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S. Barlowe, Alexendar R. Perez, Benjamin H. Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J. Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M. Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D. Nimer, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice an
Externí odkaz:
https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
Autor:
Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa Rao, John Tobias, Ryan J. Cedeno, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan, Sheila Shankar, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G. Kharas, Brian D. Gregory, Zhengquan Yu, Christopher J. Lengner
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2440-2455 (2015)
Members of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance. In contrast to the hematopoiet
Externí odkaz:
https://doaj.org/article/48f8b5528eca4e5fa6bb5060ea98df07
Autor:
Meera Dhodapkar, Katerina Hoskova, James Taggart, Thomas M. Rohwetter, Saroj Gourkanti, Angela M. Savino, Ulrich Steidl, Timothy Chou, Alexendar R. Perez, Arthur Chow, Raul Rabadan, Alexandra Schurer, Justin C. Wheat, Trevor S. Barlowe, Michael G. Kharas, Christina S. Leslie, Zhaoqi Liu, Anthony Velleca, Ersilia Barin, Camila Prieto, Ly P. Vu, Diu T.T. Nguyen
Publikováno v:
Nature cancer
RNA-binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be dysregulated in hematological malignancies. Here we identify the RBP RNA-binding motif protein, X-linked (RBMX; also known as hnRNPG), and its retroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d415274335668daddaa342161bbbd3fe
http://hdl.handle.net/10281/391390
http://hdl.handle.net/10281/391390
Autor:
Matthew Siegel, Timothy B. Gardner, Badih Joseph Elmunzer, Kerrington D. Smith, Katherine A. Morgan, Nicolas LaBarre, Trevor S. Barlowe, Sushela Chaidarun
Publikováno v:
Clinical transplantationREFERENCES. 34(7)
Islet autotransplantation (IAT) is increasingly being performed to mitigate against the diabetic complications of pancreatic resection in patients with benign inflammatory pancreatic disorders; however, the glycemic benefit of IAT in patients undergo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e641747c30282a60e52cd6a61af4ce8f
https://pubmed.ncbi.nlm.nih.gov/32356311
https://pubmed.ncbi.nlm.nih.gov/32356311
Autor:
Martin S. Tallman, Elianna M. Amin, Fatima Al-Shahrour, Glenn S. Cowley, Marcus Järås, Jeong Ah Kwon, Timothy Chou, Sagar Chhangawala, Minal Patel, Lisa P. Chu, Arora Arshi, Jacob L. Glass, Raquel P. Deering, Trevor S. Barlowe, Alexia Hwang, Patrick Tivnan, Christopher Famulare, Yuheng Lu, Benjamin L. Ebert, Ross L. Levine, Leandro Cerchietti, Scott A. Armstrong, Mithat Gonen, Michael G. Kharas, Andrei V. Krivtsov, Ari Melnick, Elisabeth Paietta, Cem Meydan, David E. Root, Nir Hacohen, Christopher J. Lengner, Gerard Minuesa, Christina S. Leslie, Camila Prieto, James Taggart, Ralph Garippa, Javier Perales-Patón, Sun Mi Park, Ly P. Vu, John G. Doench, M. Nieves Calvo-Vidal, Francine E. Garret-Bakelman, Arthur Chow
Publikováno v:
Nature genetics
The identity of the RNA binding proteins (RBPs) that govern cancer stem cell remains poorly characterized. The MSI2 RBP is a central regulator of translation of cancer stem cell programs. Through proteomics analysis of the MSI2 interacting RBP networ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb3feeff727cc124da014b2b342a31e
https://doi.org/10.1038/ng.3854
https://doi.org/10.1038/ng.3854
Autor:
Sun Mi Park, Stephen D. Nimer, Benjamin H. Durham, Patrick Tivnan, Monica L. Guzman, Trevor S. Barlowe, Alexendar R. Perez, Tzu-Chieh Ho, Gail J. Roboz, Amit Verma, James Taggart, Michael G. Kharas, Minal Patel, Rachel Okabe, Omar Abdel-Wahab, Elianna M. Amin, Ly P. Vu, Christopher J. Lengner, Christopher Famulare, Christina S. Leslie, Arthur Chow, Virginia M. Klimek, Camila Prieto, Haiming Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications
Nature Communications
Myelodysplastic syndromes (MDS) are driven by complex genetic and epigenetic alterations. The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function, but its role in MDS is unknown. Here, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bd1ea0e6161476f40b3bd9f78c72d0
https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
Autor:
Angela Nakauka-Ddamba, Kimberly Parada, Raquel P. Deering, John W. Tobias, Brian D. Gregory, Shan Wang, Ning Li, Gerard Minuesa, Shilpa Rao, Fan Li, Trevor S. Barlowe, Lee E. Vandivier, Michael G. Kharas, Maryam Yousefi, Ryan J. Cedeno, Yarden Katz, Dong Hun Woo, Shane T. Jensen, Sheila Shankar, Alexander J. Valvezan, Ammar S. Naqvi, Christopher J. Lengner, Peter S. Klein, Zhengquan Yu
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2440-2455 (2015)
SummaryMembers of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance. In contrast to the hema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3feca0e9e76188033c81f78c20a3da62
Autor:
B. Joseph Elmunzer, Nicolas LaBarre, Trevor S. Barlowe, Sushela Chaidarun, Katherine A. Morgan, Kerrington D. Smith, Matthew Siegel, Timothy B. Gardner
Publikováno v:
Gastroenterology. 158:S-343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118fb212f2de5ac9f2f35004f300431d
https://doi.org/10.1016/s0016-5085(20)31552-3
https://doi.org/10.1016/s0016-5085(20)31552-3
Autor:
Jennifer A. Punt, Anna K. Rayne, Jian Huang, Matthew Gross, Stephen G. Emerson, Ruben H. Land, Sophie Eiger, Trevor S. Barlowe, Shwetha Manjunath, Nicole R. Cunningham, Ashley N. Vanderbeck, Peter S. Klein
Publikováno v:
Stem Cells. 33:278-288
Hematopoiesis is maintained throughout life by self-renewing hematopoietic stem cells (HSCs) that differentiate to produce both myeloid and lymphoid cells. The NR4A family of orphan nuclear receptors, which regulates cell fate in many tissues, appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b52fc96f9d21f865c4cf89dca0a9b5
https://doi.org/10.1002/stem.1852
https://doi.org/10.1002/stem.1852
Autor:
Antoine Gruet, Alexandria Schurer, Trevor S. Barlowe, Hyunwoo Cho, Lauren Fairchild, Sun Mi Park, Jun Hyun Kim, James Taggart, Timothy Chou, Sagar Chhangawala, Ethan M. Shevach, Angela M. Thornton, Christina S. Leslie, Andrei V. Krivtsov, Scott A. Armstrong, Arthur Chow, Michael G. Kharas, Matthew Witkin
Publikováno v:
Cell Stem Cell. 24:153-165.e7
Leukemias exhibit a dysregulated developmental program mediated through both genetic and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function. In contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6995656b6461e101cde40557bbcbd8
https://doi.org/10.1016/j.stem.2018.10.016
https://doi.org/10.1016/j.stem.2018.10.016