Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Trevor R. Walker"'
Publikováno v:
British Journal of Pharmacology. 141:1131-1140
Neutrophil adhesion regulates a number of processes involved in the pathogenesis of inflammatory diseases including rheumatoid arthritis. Neutrophil destructive potential can be modulated by adhesion, allowing alteration of inflammatory cell behaviou
Autor:
Alan D. Pemberton, Hugh R. P. Miller, Cheryl L. Scudamore, Trevor R. Walker, T. S. Zamolodchikova, Edwin R. Chilvers
Publikováno v:
European Journal of Biochemistry. 269:1171-1180
Duodenase is a 29-kDa serine endopeptidase that displays selective trypsin- and chymotrypsin-like substrate specificity. This enzyme has been localized to epitheliocytes of Brunner's glands, and as described here, to mast cells within the intestinal
Autor:
Ian Dransfield, Christopher Haslett, Marie-Hélène Ruchaud-Sparagano, Trevor R. Walker, Adriano G. Rossi
Publikováno v:
Journal of Biological Chemistry. 275:15758-15764
Selectins play a critical role in neutrophil recruitment to sites of inflammation, in tethering and rolling of neutrophils on vascular endothelium, as well as triggering beta(2)-integrin-mediated adhesion. We have previously demonstrated potential pr
Autor:
Andrew S. Cowburn, Karen A. Cadwallader, Robert C. Rintoul, Edwin R. Chilvers, Trevor R. Walker, Alison M. Condliffe
Publikováno v:
Respiratory Research
Condliffe, A M, Cadwallader, K A, Walker, T R, Rintoul, R C, Cowburn, A S & Chilvers, E R 2000, ' Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells ', Respiratory research, vol. 1, no. 1, pp. 24 . https://doi.org/10.1186/rr8
Respiratory Research, Vol 1, Iss 1, Pp 24-29 (2000)
Condliffe, A M, Cadwallader, K A, Walker, T R, Rintoul, R C, Cowburn, A S & Chilvers, E R 2000, ' Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells ', Respiratory research, vol. 1, no. 1, pp. 24 . https://doi.org/10.1186/rr8
Respiratory Research, Vol 1, Iss 1, Pp 24-29 (2000)
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of cellular responses including survival, a
Publikováno v:
Biochemical Journal. 304:359-364
By contrast with mammalian beta-adrenergic receptors, the avian isoform elicits two distinct effector responses, activation of adenylate cyclase and polyphosphoinositide-specific phospholipase C (PLC) leading to the accumulation of both cyclic adenos
Publikováno v:
Biochemical Journal. 290:471-475
Vanadate ions in the presence of H2O2 (peroxovanadate) induce a marked increase in the degree of tyrosine phosphorylation of proteins in human platelets. This increase preceded the onset of platelet shape change and aggregation, and is associated wit
Publikováno v:
Blood. 107(12)
The selectin family of molecules (L-, P-, and E-selectin) mediates adhesive interactions between leukocytes and endothelial cells required for recruitment of leukocytes to inflammatory sites. Soluble E-selectin levels are elevated in inflammatory dis
Autor:
Morag C. Martin, Annemieke Walker, Rodger Duffin, Deborah A. Sawatzky, Adriano G. Rossi, Trevor R. Walker, Elvira Crescenzi, Alison Caldicott, Christopher Haslett, Nicola A. Riley, Tara A. Sheldrake, Ian Dransfield, Mohini Gray, John Savill, Hugh J.M. Brady, Magdalena Martinez-Losa, Carol Ward
Publikováno v:
Nature medicine
12 (2006): 1056–1064. doi:10.1038/nm1468
info:cnr-pdr/source/autori:Rossi AG; Sawatzky DA; Walker A; Ward C; Sheldrake TA; Riley NA; Caldicott A; Martinez-Losa M; Walker TR; Duffin R; Gray M; Crescenzi E; Martin MC; Brady HJ; Savill JS; Dransfield I; Haslett C./titolo:Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis/doi:10.1038%2Fnm1468/rivista:Nature medicine (Print)/anno:2006/pagina_da:1056/pagina_a:1064/intervallo_pagine:1056–1064/volume:12
12 (2006): 1056–1064. doi:10.1038/nm1468
info:cnr-pdr/source/autori:Rossi AG; Sawatzky DA; Walker A; Ward C; Sheldrake TA; Riley NA; Caldicott A; Martinez-Losa M; Walker TR; Duffin R; Gray M; Crescenzi E; Martin MC; Brady HJ; Savill JS; Dransfield I; Haslett C./titolo:Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis/doi:10.1038%2Fnm1468/rivista:Nature medicine (Print)/anno:2006/pagina_da:1056/pagina_a:1064/intervallo_pagine:1056–1064/volume:12
Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human neutrophils contain functionally active cyclin-dependent kinases (CDKs), and that structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b07eb7c5635449f1b10c3838ae461fe
Publikováno v:
British journal of pharmacology. 141(7)
1. Neutrophil adhesion regulates a number of processes involved in the pathogenesis of inflammatory diseases including rheumatoid arthritis. Neutrophil destructive potential can be modulated by adhesion, allowing alteration of inflammatory cell behav
Autor:
Karen A. Cadwallader, Jessica F. White, Edwin R. Chilvers, Alison M. Condliffe, A. McGregor, Len R. Stephens, Trevor R. Walker
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 169(6)
Neutrophil priming by agents such as TNF-α and GM-CSF causes a dramatic increase in the response of these cells to secretagogue agonists and affects the capacity of neutrophils to induce tissue injury. In view of the central role of phosphatidylinos