Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Trevor N. Johnson"'
Autor:
Matthijs W. van Hoogdalem, Ryota Tanaka, Khaled Abduljalil, Trevor N. Johnson, Scott L. Wexelblatt, Henry T. Akinbi, Alexander A. Vinks, Tomoyuki Mizuno
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 375 (2024)
Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to expected NOWS severity. To al
Externí odkaz:
https://doaj.org/article/f4fb827a797440a68bc781f557d22126
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2579 (2023)
Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug pharmacokinetics, using knowledge of the human physiology involved and drug physiochemical properties. This approach is useful when predicting drug pharmacokineti
Externí odkaz:
https://doaj.org/article/434294899da145ab94040aa16c2e264a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 854-866 (2022)
Abstract Pediatric physiologically‐based pharmacokinetic (P‐PBPK) models have been used to predict age related changes in the pharmacokinetics (PKs) of renally cleared drugs mainly in relation to changes in glomerular filtration rate. With emergi
Externí odkaz:
https://doaj.org/article/ad25f1b5a1fe4af1a98b28fe429730ae
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 373-383 (2022)
Abstract There has been a significant increase in the use of physiologically based pharmacokinetic (PBPK) models during the past 20 years, especially for pediatrics. The aim of this study was to give a detailed overview of the growth and areas of app
Externí odkaz:
https://doaj.org/article/6883167fb0144d8eb00309beb24c18c2
Autor:
Robin Michelet, Davide Bindellini, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Trevor N. Johnson, Martin J. Whitaker, Richard Ross, Charlotte Kloft
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathema
Externí odkaz:
https://doaj.org/article/d3d3a2bd751d4b2c8bcbf57951781edb
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 967-972 (2021)
Pediatric physiologically‐based pharmacokinetic (PBPK) models have broad application in the drug development process and are being used not only to project doses for clinical trials but increasingly to replace clinical studies. However, the approac
Externí odkaz:
https://doaj.org/article/fcef0e0080e344e9b7c8472297020456
Autor:
Chelsea Hosey‐Cojocari, Sherwin S. Chan, Chance S. Friesen, Amie Robinson, Veronica Williams, Erica Swanson, Daniel O’Toole, Jansynn Radford, Neil Mardis, Trevor N. Johnson, J. Steven Leeder, Valentina Shakhnovich
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 2008-2016 (2021)
Abstract The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size ch
Externí odkaz:
https://doaj.org/article/c2ad65bb111b4df6b1b9edc8e96c7e72
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1922 (2023)
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in gast
Externí odkaz:
https://doaj.org/article/2468fe3045fc4204a335aa9142c80122
Autor:
Bianca D. vanGroen, Venkatesh Pilla Reddy, Justine Badée, Andrés Olivares‐Morales, Trevor N. Johnson, Johan Nicolaï, Pieter Annaert, Anne Smits, Saskia N. deWildt, Catherijne A. J. Knibbe, Loeckie deZwart
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 29-35 (2021)
On April 24, 2019, a symposium on Pediatric Pharmacokinetics and Dose Predictions was held as a satellite meeting to the 10th Juvenile Toxicity Symposium. This symposium brought together scientists from academia, industry, and clinical research organ
Externí odkaz:
https://doaj.org/article/690f10a798a64e0ea88774b713cf9363
Autor:
Chie Emoto, Trevor N. Johnson, David Hahn, Uwe Christians, Rita R. Alloway, Alexander A. Vinks, Tsuyoshi Fukuda
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 273-284 (2019)
Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A P
Externí odkaz:
https://doaj.org/article/2417614322424306a3f5384a8e116391