Zobrazeno 1 - 6
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pro vyhledávání: '"Trevor M. Morey"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to determine the half-life of cellular proteins that overcomes the limitations of other commonl
Externí odkaz:
https://doaj.org/article/ef0ce01a37254f96849064e34697a6ad
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduce
Externí odkaz:
https://doaj.org/article/6f7e430a223a47008176558d502ad9dd
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to determine the half-life of cellular proteins that overcomes the limitations of other commonl
Publikováno v:
Journal of Neurochemistry. 137:630-646
Choline acetyltransferase (ChAT) is essential for cholinergic neuron function as it mediates synthesis of the neurotransmitter acetylcholine. ChAT mutations have been linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-
Publikováno v:
Journal of Biological Chemistry. 290:11443-11454
Hyperthermia is a proteotoxic stress that is lethal when exposure is extreme but also cytoprotective in that sublethal exposure leads to the synthesis of heat shock proteins, including HSP70, which are able to inhibit stress-induced apoptosis. CDK5 i
Autor:
Warren Winick-Ng, Bryan Heit, Trevor M. Morey, Jennifer Winick-Ng, R. Jane Rylett, Fabiana A. Caetano
Publikováno v:
Scientific Reports
The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of acute exposure to oligomeric amyloid-β1–42 (Aβ1–42) on 82-kDa ChA