Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Trevor M Darby"'
Autor:
Abdul Malik Tyagi, Trevor M Darby, Emory Hsu, Mingcan Yu, Subhashis Pal, Hamid Dar, Jau-Yi Li, Jonathan Adams, Rheinallt M Jones, Roberto Pacifici
Publikováno v:
eLife, Vol 10 (2021)
Genetic factors account for the majority of the variance of human bone mass, but the contribution of non-genetic factors remains largely unknown. By utilizing maternal/offspring transmission, cohabitation, or fecal material transplantation (FMT) stud
Externí odkaz:
https://doaj.org/article/3d3a8ba006e04469b2b6921f726d587e
Autor:
Caitlin V. Lewis, Hassan Sellak, Mariem A. Sawan, Giji Joseph, Trevor M. Darby, David VanInsberghe, Crystal R. Naudin, David R. Archer, Rheinallt M. Jones, W. Robert Taylor
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 199-210 (2023)
Abstract The intestinal microbiome has emerged as a potential contributor to the severity of sickle cell disease (SCD). We sought to determine whether SCD mice exhibit intestinal barrier dysfunction, inflammation, and dysbiosis. Using the Townes huma
Externí odkaz:
https://doaj.org/article/286f62f9ca5f48d3a0d039d671dbac67
Autor:
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones, PhD
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1311-1327 (2021)
Background & Aims: In colorectal cancer, approximately 95% of patients are refractory to immunotherapy because of low antitumor immune responses. Therefore, there is an exigent need to develop treatments that increase antitumor immune responses and d
Externí odkaz:
https://doaj.org/article/d5aeedf4ef0c419c9be554d0efabc4c5
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 627-639 (2020)
Background & Aims: Identifying the functional elements that mediate efficient gut epithelial growth and homeostasis is essential for understanding intestinal health and disease. Many of these processes involve the Lactobacillus-induced generation of
Externí odkaz:
https://doaj.org/article/e87ae3f2232940a78956e4ffa4db69cd
Autor:
Alexandra A. Wolfarth, Xu Liu, Trevor M. Darby, Darra J. Boyer, Jocelyn B. Spizman, Joshua A. Owens, Bindu Chandrasekharan, Crystal R. Naudin, Krisztina Z. Hanley, Brian S. Robinson, Eric A. Ortlund, Rheinallt M. Jones, Andrew S. Neish
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 713-727 (2020)
Background & Aims: The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment from the microbial and antigenic components of the gut lumen. Identifying proteins that me
Externí odkaz:
https://doaj.org/article/4a0ec09a3c3648728968dcc3d9a1343a
Autor:
Trevor M. Darby, Joshua A. Owens, Bejan J. Saeedi, Liping Luo, Jason D. Matthews, Brian S. Robinson, Crystal R. Naudin, Rheinallt M. Jones
Publikováno v:
iScience, Vol 12, Iss , Pp 356-367 (2019)
Summary: The use of beneficial bacteria to promote health is widely practiced. However, experimental evidence corroborating the efficacy of bacteria promoted with such claims remains limited. We address this gap by identifying a beneficial bacterium
Externí odkaz:
https://doaj.org/article/711b1f38f787445d962489da4175aaad
Autor:
Jason D. Matthews, April R. Reedy, Huixia Wu, Benjamin H. Hinrichs, Trevor M. Darby, Caroline Addis, Brian S. Robinson, Young-Mi Go, Dean P. Jones, Rheinallt M. Jones, Andrew S. Neish
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 526-532 (2019)
Intestinal homeostasis is regulated in-part by reactive oxygen species (ROS) that are generated in the colonic mucosa following contact with certain lactobacilli. Mechanistically, ROS can modulate protein function through the oxidation of cysteine re
Externí odkaz:
https://doaj.org/article/9f5023c7678749618cba0f3b0b041aa1
Autor:
Rheinallt M. Jones, Chirayu Desai, Trevor M. Darby, Liping Luo, Alexandra A. Wolfarth, Christopher D. Scharer, Courtney S. Ardita, April R. Reedy, Erin S. Keebaugh, Andrew S. Neish
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1217-1225 (2015)
An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in symbiont-induced host responses have not yet been fully characterized. Here, we report that cellular R
Externí odkaz:
https://doaj.org/article/c3843f02a57c4973b4a59b9d689534f4