Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Trevor M, Lewis"'
1
Akademický článek
Effects of Removing User-Land Hooks in Endpoint Protection During Attack Experiments
Autor: Trevor M. Lewis, Bhaskar P. Rimal
Publikováno v: IEEE Access, Vol 12, Pp 15820-15844 (2024)
This paper conducts research on current-generation Endpoint Detection and Response (EDR) solution design that identifies fundamental gaps in the prevention and detection of malicious cyber techniques. These fundamental gaps are the result of using
Externí odkaz: https://doaj.org/article/bb866fe34e7c4bd0964168e223548d23
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2
Akademický článek
Ligand Binding at the 4-4 Agonist-Binding Site of the 42 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State.
Autor: Dinesh C Indurthi, Trevor M Lewis, Philip K Ahring, Thomas Balle, Mary Chebib, Nathan L Absalom
Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161154 (2016)
The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant subtype in the brain and exists in two functional stoichiometries: (α4)3(β2)2 and (α4)2(β2)3. A distinct feature of the (α4)3(β2)2 receptor is the biphasic activation resp
Externí odkaz: https://doaj.org/article/dfa577d162d24b8f8d571661cf190213
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3
Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry
Autor: Thomas Balle, Dinesh C. Indurthi, Nathan L. Absalom, Philip K. Ahring, Trevor M. Lewis, Taima Qudah, Vivian Wan Yu Liao, Mary Chebib
Publikováno v: Pharmacological Research. 139:215-227
Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a genetic form of epilepsy that is caused by mutations in several genes, including genes encoding for the α4 and β2 subunits of the nicotinic acetylcholine (nACh) receptor. Pentameric
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc315e83fdb8f6ee1fac168ea9eb8ed8
https://doi.org/10.1016/j.phrs.2018.11.031
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5
Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures
Autor: Kei Eto, John M. Power, Hiroyuki Inada, Watanabe M, Oba T, Donna Lai, Chelsea S. Goulton, Dennis Lawrence Cheung, Khoshaba A, Trevor M. Lewis, Junichi Nabekura, Gary D. Housley, Hiroaki Wake, Nakamura K, Wang K, Andrew J. Moorhouse
/SummaryEfficacious neuronal inhibition is sustained by the neuronal K+Cl- co-transporter KCC2, and loss of KCC2 function through injury or mutation is associated with altered GABAergic signalling and neuronal seizures. Here we report a transgenic mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6fda68b3ef27cee8982b242582663a
https://doi.org/10.1101/253831
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7
A Hydrophobic Area of the GABA ρ1 Receptor Containing Phenylalanine 124 Influences Both Receptor Activation and Deactivation
Autor: Trevor M. Lewis, Izumi Yamamoto, Heba Abdel-Halim, Jane E. Carland, Jane R. Hanrahan, Mary Chebib, Nathan L. Absalom
Publikováno v: Journal of Molecular Neuroscience. 55:305-313
Experimental evidence suggests that GABA ρ1 receptors are potential therapeutic targets for the treatment of a range of neurological conditions, including anxiety and sleep disorders. Homology modelling of the GABA ρ1 extracellular N-terminal domai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3f77d07e560548fde516dc53bc07ae6
https://doi.org/10.1007/s12031-014-0322-7
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8
Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin
Autor: Ruby C.Y. Lin, Vladimir Sytnyk, Thomas Duncan, Kuldip S. Sidhu, Trevor M. Lewis, Michael Valenzuela, Aileen Lowe, Perminder S. Sachdev
Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 2, Pp 557-570 (2017)
Summary Repopulation of brain circuits by neural precursors is a potential therapeutic strategy for neurodegenerative disorders; however, choice of cell is critical. Previously, we introduced a two-step culture system that generates a high yield of n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8190f7a6876e61ad7e55b3b39422c3
https://pubmed.ncbi.nlm.nih.gov/28793248
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9
Covalent Trapping of Methyllycaconitine at the α4-α4 Interface of the α4β2 Nicotinic Acetylcholine Receptor
Autor: Gracia X. J. Quek, Joseph I. Ambrus, Nathan L. Absalom, Thomas Balle, Kasper Harpsøe, Nasiara Karim, Taima Qudah, Malcolm D. McLeod, Trevor M. Lewis, Mary Chebib, Ida von Arenstorff
Publikováno v: Journal of Biological Chemistry. 288:26521-26532
The α4β2 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the brain and are implicated in a variety of physiological processes. There are two stoichiometries of the α4β2 nAChR, (α4)2(β2)3 and (α4)3(β2)2, with different sensi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fbc9d77114934abec6604994ac95317
https://doi.org/10.1074/jbc.m113.475053
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10
An optimised 3 M KCl salt-bridge technique used to measure and validate theoretical liquid junction potential values in patch-clamping and electrophysiology
Autor: Andrew J. Moorhouse, Trevor M. Lewis, Peter H. Barry
Publikováno v: European Biophysics Journal. 42:631-646
Accurate potential measurements in electrophysiological experiments require correction for liquid junction potentials (LJPs), and, in patch-clamping especially, these can often be ~5-10 mV or more. They can be either calculated, if ion mobilities are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3501907f59b45489eeee680db9a6c8f0
https://doi.org/10.1007/s00249-013-0911-3
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