Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Trevor K Archer"'
Publikováno v:
eLife, Vol 8 (2019)
The SWI/SNF complex is a critical regulator of pluripotency in human embryonic stem cells (hESCs), and individual subunits have varied and specific roles during development and in diseases. The core subunit SMARCB1 is required for early embryonic sur
Externí odkaz:
https://doaj.org/article/802f4167aa9246da8c5f3c659268b432
Publikováno v:
eLife, Vol 7 (2018)
The Glucocorticoid Receptor (GR) alters transcriptional activity in response to hormones by interacting with chromatin at GR binding sites (GBSs) throughout the genome. Our work in human breast cancer cells identifies three classes of GBSs with disti
Externí odkaz:
https://doaj.org/article/f5c6465725fc45508379b37933ff4a19
Autor:
Christopher A Lavender, Kimberly R Cannady, Jackson A Hoffman, Kevin W Trotter, Daniel A Gilchrist, Brian D Bennett, Adam B Burkholder, Craig J Burd, David C Fargo, Trevor K Archer
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006224 (2016)
Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene
Externí odkaz:
https://doaj.org/article/2f0d439aff5d4fce89f99d8a68cb7f3b
Autor:
Gang Ren, Wai Lim Ku, Guangzhe Ge, Jackson A. Hoffman, Jee Youn Kang, Qingsong Tang, Kairong Cui, Yong He, Yukun Guan, Bin Gao, Chengyu Liu, Trevor K. Archer, Keji Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The mammalian SWI/SNF-like BAF complexes play critical roles during animal development and pathological conditions. Previous gene deletion studies and characterization of human gene mutations implicate that the complexes both repress and act
Externí odkaz:
https://doaj.org/article/8a8944bb333045159cd21cd42b4aefdb
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23490 (2011)
Nucleosomes can block access to transcription factors. Thus the precise localization of nucleosomes relative to transcription start sites and other factor binding sites is expected to be a critical component of transcriptional regulation. Recently de
Externí odkaz:
https://doaj.org/article/06c82da64cb54d59afe92d863dbe778d
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3001 (2008)
BackgroundEmbryonic stem (ES) cells self-renew as coherent colonies in which cells maintain tight cell-cell contact. Although intercellular communications are essential to establish the basis of cell-specific identity, molecular mechanisms underlying
Externí odkaz:
https://doaj.org/article/bf3348547fa0475f8b9984de20191ba8
Autor:
Farideh Shafiee-Kermani, Skyla T. Carney, Dereje Jima, Utibe C. Utin, LaNeisha B. Farrar, Melvin O. Oputa, Marcono R. Hines, H. Karimi Kinyamu, Kevin W. Trotter, Trevor K. Archer, Cathrine Hoyo, Beverly H. Koller, Stephen J. Freedland, Delores J. Grant
Publikováno v:
Epigenetics, Vol 16, Iss 3, Pp 289-299 (2021)
Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign
Externí odkaz:
https://doaj.org/article/b07d19108d254966ae0dcb681885e3bb
Autor:
Nolan G. Gokey, James M. Ward, Eric J. Milliman, Leesa J. Deterding, Kevin W. Trotter, Trevor K. Archer
The Chromatosome superstructure, comprised of core histone containing nucleosomes and linker histones, act in concert as physical barriers to genetic material in the mammalian nucleus to trans-acting factors. Appropriate arrangement, composition, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4dab22b753a4b3ef14ea5c39aaf37b4
https://doi.org/10.1101/2023.05.14.540702
https://doi.org/10.1101/2023.05.14.540702
Autor:
Francis S. Collins, Mia Rochelle Lowden, Lawrence A. Tabak, Victoria Rucker, Marie A. Bernard, Trevor K. Archer, Tara A. Schwetz, Sadhana Jackson, Julia A. Segre, Ericka Boone, Monica Webb Hooper, Nih Unite, Amy Bany Adams, Alfred C. Johnson, John Burklow, Anna E. Ordóñez, Jon R. Lorsch, Anna María Nápoles, Robert Rivers, Carrie D. Wolinetz, Michele K. Evans, Courtney Aklin
Publikováno v:
Cell. 184:3075-3079
NIH has acknowledged and committed to ending structural racism. The framework for NIH's approach, summarized here, includes understanding barriers; developing robust health disparities/equity research; improving its internal culture; being transparen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3200223815edd8a6462578fa303566
https://doi.org/10.1016/j.cell.2021.05.014
https://doi.org/10.1016/j.cell.2021.05.014
Autor:
Calvin S. Leung, Oksana Kosyk, Emma M. Welter, Nicholas Dietrich, Trevor K. Archer, Anthony S. Zannas
Publikováno v:
iScience. 25(9)
Chronic environmental stress can profoundly impact cell and body function. Although the underlying mechanisms are poorly understood, epigenetics has emerged as a key link between environment and health. The genomic effects of stress are thought to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652d3a66063c1fb7c7fe9d940d7c068f
https://pubmed.ncbi.nlm.nih.gov/36065188
https://pubmed.ncbi.nlm.nih.gov/36065188