Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Trevor J. Kilpatrick"'
Autor:
Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick, Michele D. Binder
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Microglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and colonise all regions of the CNS early in development. Microglia have been demonstrated to p
Externí odkaz:
https://doaj.org/article/66c5eab9da904e769dbf169a1ab0c23c
Autor:
Alexander D. Walsh, Sarrabeth Stone, Saskia Freytag, Andrea Aprico, Trevor J. Kilpatrick, Brendan R. E. Ansell, Michele D. Binder
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Microglia regulate multiple processes in the central nervous system, exhibiting a considerable level of cellular plasticity which is facilitated by an equally dynamic transcriptional environment. While many gene networks that regulate microg
Externí odkaz:
https://doaj.org/article/38de1b89c4074016a7cfc2ccfcc14aef
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15903 (2023)
Many treatments for autoimmune diseases, caused by the loss of immune self-tolerance, are broadly immunosuppressive. Dendritic cells (DCs) can be induced to develop anti-inflammatory/tolerogenic properties to suppress aberrant self-directed immunity
Externí odkaz:
https://doaj.org/article/c0ef092d48794ae1a08ee4d1da513bcc
Autor:
Yao Lulu Xing, Jasmine Poh, Bernard H.A. Chuang, Kaveh Moradi, Stanislaw Mitew, William D. Richardson, Trevor J. Kilpatrick, Yasuyuki Osanai, Tobias D. Merson
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 2, Pp 100414- (2023)
Summary: Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent CNS have limitations in the extent and duration of OPC depletion. We have developed a pharmacogenetic approach for conditional OP
Externí odkaz:
https://doaj.org/article/ac75dafd8a5c4a4eab2d291381dfd8b3
Autor:
Curtis M. Hay, Stacey Jackson, Stanislaw Mitew, Daniel J. Scott, Matthias Koenning, AeSoon L. Bensen, Helena Bujalka, Trevor J. Kilpatrick, Ben Emery
Publikováno v:
Neural Development, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract Background Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin in order to allow rapid electrical conduction. Establishing the
Externí odkaz:
https://doaj.org/article/159a6260f6b64efdab878264bb9636be
Autor:
Minh N. L. Nguyen, Chao Zhu, Scott C. Kolbe, Helmut Butzkueven, Owen B. White, Joanne Fielding, Trevor J. Kilpatrick, Gary F. Egan, Alexander Klistorner, Anneke van der Walt
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundPredicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lack
Externí odkaz:
https://doaj.org/article/be94646d4bf141bf9437d8c3efe16a30
Autor:
Tiago Medeiros-Furquim, Sinan Ayoub, Laura J. Johnson, Andrea Aprico, Eze Nwoke, Michele D. Binder, Trevor J. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cladribine (2-chlorodeoxyadenosine, 2CdA) is one of the most effective disease-modifying drugs for multiple sclerosis (MS). Cladribine is a synthetic purine nucleoside analog that induces cell death of lymphocytes and oral cladribine treatment leads
Externí odkaz:
https://doaj.org/article/94ed270034be42b9873adc2296416d2a
Autor:
Laura Clarke, Simon Arnett, Wajih Bukhari, Elham Khalilidehkordi, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M. Prain, Mark Woodhall, Roger Silvestrini, Christine S. Bundell, David A. Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J. Brew, Wallace Brownlee, Helmut Butzkueven, William M. Carroll, Cella Chen, Alan Coulthard, Russell C. Dale, Chandi Das, Marzena J. Fabis-Pedrini, David Gillis, Simon Hawke, Robert Heard, Andrew P. D. Henderson, Saman Heshmat, Suzanne Hodgkinson, Trevor J. Kilpatrick, John King, Christopher Kneebone, Andrew J. Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christopher Lynch, Richard A. L. Macdonell, Deborah F. Mason, Pamela A. McCombe, Jennifer Pereira, John D. Pollard, Sudarshini Ramanathan, Stephen W. Reddel, Cameron P. Shaw, Judith M. Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C. Wong, Eppie M. Yiu, Michael H. Barnett, Allan G. K. Kermode, Mark P. Marriott, John D. E. Parratt, Mark Slee, Bruce V. Taylor, Ernest Willoughby, Fabienne Brilot, Angela Vincent, Patrick Waters, Simon A. Broadley
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of eva
Externí odkaz:
https://doaj.org/article/9881dfe6e71f44f48b35ffd764478289
Autor:
Christopher M. Dwyer, Linda Thien-Trang Nguyen, Luke M. Healy, Ranjan Dutta, Samuel Ludwin, Jack Antel, Michele D. Binder, Trevor J. Kilpatrick
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
We propose that multiple sclerosis (MS) is best characterized as a syndrome rather than a single disease because different pathogenetic mechanisms can result in the constellation of symptoms and signs by which MS is clinically characterized. We descr
Externí odkaz:
https://doaj.org/article/5baec7b0bb934dbbb2f805c1e6e474a4
Autor:
Farrah Blades, Vickie H. Y. Wong, Christine T. O. Nguyen, Bang V. Bui, Trevor J. Kilpatrick, Michele D. Binder
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons and transmitting information to the visual centers of the brain. The death of RGCs is a common outcome in many optic ne
Externí odkaz:
https://doaj.org/article/a75420c624ad493c93d1b8492dc2b394