Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Trevor J. Gonzalez"'
Autor:
Mercedes Barzi, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, Yunhan Ma, Sabrina Collias, Sarah E. Woodfield, Anna Mae Diehl, Sanjeev A. Vasudevan, Thao N. Galvan, John Goss, Charles A. Gersbach, Beatrice Bissig-Choisat, Aravind Asokan, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver chimeric transgene-free Il2rg −/
Externí odkaz:
https://doaj.org/article/3464bdb424c442108002dbd891da2d8d
Autor:
Ezra J. Loeb, Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, Aravind Asokan
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113902- (2024)
Summary: Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By sw
Externí odkaz:
https://doaj.org/article/80e360eb884e4f9ebe6cb54049ee9c77
Autor:
Valentina Cigliola, Adam Shoffner, Nutishia Lee, Jianhong Ou, Trevor J. Gonzalez, Jiaul Hoque, Clayton J. Becker, Yanchao Han, Grace Shen, Timothy D. Faw, Muhammad M. Abd-El-Barr, Shyni Varghese, Aravind Asokan, Kenneth D. Poss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords produce the neurogenic factor Hb-egfa upon transection injury
Externí odkaz:
https://doaj.org/article/2737da5baae64c2ead8e371c7a519559
Autor:
Trevor J. Gonzalez, Katherine E. Simon, Leo O. Blondel, Marco M. Fanous, Angela L. Roger, Maribel Santiago Maysonet, Garth W. Devlin, Timothy J. Smith, Daniel K. Oh, L. Patrick Havlik, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, Mai K. ElMallah, Charles A. Gersbach, Aravind Asokan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow therapeutic window. Effective clinical translation is confounded, at least in part
Externí odkaz:
https://doaj.org/article/d9d15ee20e5e46a9b86982294d7e7093
Autor:
Mercedes Barzi, Collin G. Johnson, Tong Chen, Ramona M. Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, James Beasley, Cheryl K. Peck, Yunhan Ma, Ashlee R. Stiles, Timothy C. Wood, Raquel Maeso-Diaz, Anna Mae Diehl, Sarah P. Young, Jeffrey I. Everitt, William C. Wetsel, William R. Lagor, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig
Publikováno v:
Science Translational Medicine. 15
Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl–coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism. Current literature suggests that toxic
Autor:
Mercedes Barzi, Collin Johnson, Tong Chen, Ramona Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, James Beasley, Yunhan Ma, Ashlee R. Stiles, Timothy C. Wood, Raquel Maeso-Diaz, Ana Mae Diehl, Sarah P. Young, Jeffrey I. Everitt, William C. Wetsel, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig
Publikováno v:
Molecular Genetics and Metabolism. 138:107377
Autor:
Yuan Lu, Sean M. Walter, Markita G. Savage, Mikki Boswell, Geraldo Medrano, Rebecca Marks, Jose Reyes, Raquel Salinas, Ronald B. Walter, Wesley C. Warren, Trevor J. Gonzalez, Manfred Schartl, William T. Boswell
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-14 (2020)
BMC Genomics
BMC Genomics
BackgroundStudying functional divergences between paralogs that originated from genome duplication is a significant topic in investigating molecular evolution. Genes that exhibit basal level cyclic expression patterns including circadian and light re
Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy
Autor:
Aravind Asokan, Jixue Li, Marek Napierala, Yanjie Li, Trevor J. Gonzalez, Jill S. Napierala, Jun Wang
Publikováno v:
Hum Gene Ther
Friedreich's ataxia (FRDA) is the most common inherited form of ataxia in humans. It is caused by severe downregulation of frataxin (FXN) expression instigated by hyperexpansion of the GAA repeats located in intron 1 of the FXN gene. Despite numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c40a411166989c7a3691b1460a6785
https://europepmc.org/articles/PMC7462031/
https://europepmc.org/articles/PMC7462031/
Autor:
Geraldo Medrano, Sean M. Walter, Jose Reyes, William T. Boswell, Yuan Lu, Markita G. Savage, Ronald B. Walter, Trevor J. Gonzalez, Mikki Boswell
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 208:2-11
Evolutionarily conserved diurnal circadian mechanisms maintain oscillating patterns of gene expression based on the day-night cycle. Xiphophorus fish have been used to evaluate transcriptional responses after exposure to various light sources and it
Autor:
Trevor J. Gonzalez, George E. Sanders, Samuel Ellis, Sean M. Walter, Yuan Lu, William T. Boswell, Mikki Boswell, Geraldo Medrano, Christian Lawrence, Zoltán M. Varga, Ronald B. Walter, Markita G. Savage
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 208
Artificial light produces an emission spectrum that is considerably different than the solar spectrum. Artificial light has been shown to affect various behavior and physiological processes in vertebrates. However, there exists a paucity of data rega