Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Trevor J. Biden"'
Autor:
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K. Boyer, Ashleigh M. Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B. Stephens, Kazunori Imaizumi, Trevor J. Biden
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101845- (2024)
Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum (ER) and incorporation into i
Externí odkaz:
https://doaj.org/article/abf43cfa76f149028ed91ecd5b7f85a5
Autor:
Le May Thai, Liam O’Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A. Kebede, Robert Brink, Gregory J. Cooney, Katharine M. Irvine, Samuel N. Breit, Tri G. Phan, Alexander Swarbrick, Trevor J. Biden
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106477- (2023)
Summary: We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling) polarization. Unde
Externí odkaz:
https://doaj.org/article/f164ff5bf0454edab4a24997c1c6486a
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101023- (2020)
Objective: Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiting glucose-stimulated insulin secretion (GSIS), potentially involving remodelling of cellular lipids, have been suggest
Externí odkaz:
https://doaj.org/article/cd418bc34d88406ab306ca4bce735f48
Autor:
Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J. Meikle, Trevor J. Biden
Publikováno v:
Molecular Metabolism, Vol 5, Iss 6, Pp 404-414 (2016)
Objective: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. Methods:
Externí odkaz:
https://doaj.org/article/e7690088ab7b4cae98abb75ccb8be222
Autor:
Sarita Dhounchak, Sarah K Popp, Debra J Brown, D Ross Laybutt, Trevor J Biden, Stefan R Bornstein, Christopher R Parish, Charmaine J Simeonovic
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252607 (2021)
Heparan sulfate proteoglycans (HSPGs) consist of a core protein with side chains of the glycosaminoglycan heparan sulfate (HS). We have previously identified (i) the HSPGs syndecan-1 (SDC1), and collagen type XVIII (COL18) inside mouse and human isle
Externí odkaz:
https://doaj.org/article/68eb3c59062444408e639f2ff92b388d
Autor:
Trevor J. Biden, Gemma L. Pearson, Scott A. Soleimanpour, Morgan A. Gingerich, Emily M. Walker
Publikováno v:
Diabetes
Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a principal driver of diabetes development. To preserve optimal health β-cells must withstand both intrinsic and extrinsic stressors, ranging from inflamm
Autor:
Ashley Hertzog, Trevor J. Biden, Josephine Yu, Nigel Turner, Adviye Ayper Tolun, Nicola J. Smith, Simon H. J. Brown, Azrah Samsudeen, Gregory J. Cooney, Amanda E. Brandon, Beena Devanapalli, Corrine E. Fiveash, Todd W. Mitchell, Magdalene K. Montgomery, Brenna Osborne, Liam O’Reilly, Brendan P. Wilkins, Tomas Kavanagh, Antony A. Cooper
Publikováno v:
FASEB J
Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid (MCFA) receptor G‐protein‐coupled receptor (Gpr) 84 in skeletal muscle mitochondrial
Autor:
Liam O’Reilly, Natalie A. Mellet, Peter J. Meikle, Trevor J. Biden, Kwan Yi Chu, Clarissa Bartley
Publikováno v:
Journal of Biological Chemistry. 294:1218-1229
Autophagy is critical for maintaining cellular function via clearance of excess nutrients and damaged organelles. In pancreatic β-cells, it helps counter the endoplasmic reticulum (ER) stress that impairs insulin secretory capacity during Type 2 dia
Autor:
Sarah K. Popp, Christopher R. Parish, Charmaine J. Simeonovic, Trevor J. Biden, Sarita Dhounchak, D. Ross Laybutt, Debra J. Brown, Stefan R. Bornstein
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252607 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252607 (2021)
Heparan sulfate proteoglycans (HSPGs) consist of a core protein with side chains of the glycosaminoglycan heparan sulfate (HS). We have previously identified (i) the HSPGs syndecan-1 (SDC1), and collagen type XVIII (COL18) inside mouse and human isle
Autor:
Magdalene K. Montgomery, Camille Devereux, Matthew J. Watt, Jacqueline Bayliss, Cheng Huang, David Roberts, Scott L. Townley, Dorit Samocha-Bonet, Ayenachew Bezawork-Geleta, Ruth C. R. Meex, Ralf B. Schittenhelm, Andrew Ryan, Gregory R. Steinberg, Trevor J. Biden, Luke A. Selth
Publikováno v:
Science Translational Medicine, 12(559):8048. American Association for the Advancement of Science
Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose-responsive hepatokine and regulator of gluco