Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Trevor H. Thomas"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162908 (2016)
Cardiovascular disease and cancer are increased in Type 2 diabetes. TPM1 and TPM4 genes encode proteins associated with cardiovascular and neoplastic disease. High (HMW) and low (LMW) molecular weight isoforms from TPM1 and TPM4 are altered in severa
Externí odkaz:
https://doaj.org/article/0863099fce26429fb19b81e0948b5e31
Publikováno v:
Journal of Cellular Biochemistry. 113:3576-3586
High and low molecular weight (LMW) tropomyosin isoforms, by regulation of actin filaments, have a major role in the regulation of cell behaviour. They affect malignant transformation, motility, differentiation, metastasis and cell membrane protein p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fdaf1c792b0dca12517fb63972b009
https://doi.org/10.1002/jcb.24236
https://doi.org/10.1002/jcb.24236
Publikováno v:
Molecular Immunology. 46:1405-1408
There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of IgA nephropathy. Mesangial C3 deposition is seen in approximately 90% of patients and polymeric IgA has been shown to activate the alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baead4c5cc937afbd116bad442e12a2
https://doi.org/10.1016/j.molimm.2008.12.002
https://doi.org/10.1016/j.molimm.2008.12.002
Autor:
Trevor H. Thomas, A Advani
Publikováno v:
Cardiovascular & Hematological Agents in Medicinal Chemistry. 4:165-182
Cardiovascular disease is prevalent in developed countries causing very large burdens to health services. The underlying pathology is atheromatous plaque in the sub-endothelial region of the vascular wall. High levels of low density lipoprotein chole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8cecd2a78603140a0e939313b66972
https://doi.org/10.2174/187152506776369926
https://doi.org/10.2174/187152506776369926
Publikováno v:
Clinical Science. 108:231-236
A polymorphism of the α-subunit of adducin, Gly 460 → Trp, may affect membrane ion transport and be associated with human EH (essential hypertension). The α-adducin Gly 460 → Trp polymorphism was determined in 242 NC (normal controls) and 73 pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a88b3122c9430b34e612ca7b6173ae
https://doi.org/10.1042/cs20040267
https://doi.org/10.1042/cs20040267
Publikováno v:
Nephrology Dialysis Transplantation. 17:79-87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36829599d4bff3a5e038ea1cdb9a46da
https://doi.org/10.1093/ndt/17.suppl_12.79
https://doi.org/10.1093/ndt/17.suppl_12.79
Publikováno v:
Diabetologia. 45:719-727
Neutrophil dysfunction has a role in the pathogenesis of complications in Type II (non-insulin-dependent) diabetes mellitus. Neutrophils adhere through expression of the beta(2)integrin CD11b/CD18 which closely associates with the actin cytoskeleton.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a531c106d1ac48c98219f8bb447a5b1a
https://doi.org/10.1007/s00125-002-0802-0
https://doi.org/10.1007/s00125-002-0802-0
Publikováno v:
Clinical Science. 102:69-75
Microalbuminuria in Type I diabetes involves a cell membrane abnormality and is associated with a large increase in cardiovascular risk. The hypothesis that the membrane abnormality alters granule exocytosis in neutrophils, which could contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020f6d567f090a7d43acf726f1615603
https://doi.org/10.1042/cs1020069
https://doi.org/10.1042/cs1020069
Publikováno v:
Journal of Hypertension. 19:485-493
Objectives To identify a thiol protein that is abnormal in a subgroup of essential hypertensive (EHT) patients who have a strong family history of hypertension and cardiovascular disease and have a low Km of erythrocyte Na/Li countertransport (CT). M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06c9090d9b6144d990ae9c4852451f6
https://doi.org/10.1097/00004872-200103000-00017
https://doi.org/10.1097/00004872-200103000-00017
Publikováno v:
Clinical Science. 98:673-680
In essential hypertension and diabetic nephropathy, sodium-lithium countertransport (Na-Li CT) is an inherited marker, subject to metabolic influences, of cardiovascular risk. Studies in Type II diabetes, taking clinical phenotypes as their starting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9eea8827822c7dcb68af3317057852
https://doi.org/10.1042/cs0980673
https://doi.org/10.1042/cs0980673