Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Trevor G Shepherd"'
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
Jessica G Tong, Yudith Ramos Valdes, John W Barrett, John C Bell, David Stojdl, Grant McFadden, J Andrea McCart, Gabriel E DiMattia, Trevor G Shepherd
Publikováno v:
Molecular Therapy: Oncolytics, Vol 2, Iss , Pp - (2015)
Epithelial ovarian cancer is unique among most carcinomas in that metastasis occurs by direct dissemination of malignant cells traversing throughout the intraperitoneal fluid. Accordingly, we test new therapeutic strategies using an in vitro three-di
Externí odkaz:
https://doaj.org/article/c244a8fac6094fe2bac70100a0881479
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium. Therapeutic intervention occurs at adva
Externí odkaz:
https://doaj.org/article/c7bf5f55cad149e0a8bb3f0ae7f7d9d6
Autor:
David P. Cook, Kristianne J. C. Galpin, Galaxia M. Rodriguez, Noor Shakfa, Juliette Wilson-Sanchez, Maryam Echaibi, Madison Pereira, Kathy Matuszewska, Jacob Haagsma, Humaira Murshed, Alison O. Cudmore, Elizabeth MacDonald, Alicia Tone, Trevor G. Shepherd, James J. Petrik, Madhuri Koti, Barbara C. Vanderhyden
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Ovarian cancers exhibit high rates of recurrence and poor treatment response. Preclinical models that recapitulate human disease are critical to develop new therapeutic approaches. Syngeneic mouse models allow for the generation of tumours c
Externí odkaz:
https://doaj.org/article/f661987fb8f3474ebc28deb27ada3401
Autor:
Jacob Haagsma, Bart Kolendowski, Adrian Buensuceso, Yudith Ramos Valdes, Gabriel E. DiMattia, Trevor G. Shepherd
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cel
Externí odkaz:
https://doaj.org/article/ad1278351c7a4573a46854595d9528d2
Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems
Autor:
Emily Tomas, Trevor G. Shepherd
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we delve into the concept of tumour dormancy, where cells transition between proliferative and dorm
Externí odkaz:
https://doaj.org/article/f7ca057c0d974e3f9933930835ac202a
Autor:
Jeremi Laski, Bipradeb Singha, Xu Wang, Yudith Ramos Valdés, Olga Collins, Trevor G. Shepherd
Publikováno v:
Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-12 (2020)
Abstract Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity. EOC spheroids are subjected to bioenerg
Externí odkaz:
https://doaj.org/article/d44607b4db7c43318a272741054f58d9
Autor:
Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia, Trevor G. Shepherd
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)
Abstract Background Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an emerging oncolytic, Maraba virus (MRBV), in an
Externí odkaz:
https://doaj.org/article/6a1cbebf497f445e8c0b199b1dcd720a
Immunohistochemical scoring of cleaved caspase 3 in EOC xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ea25701010550ef5a0b362208f7006
https://doi.org/10.1158/1541-7786.22514370
https://doi.org/10.1158/1541-7786.22514370
Single OVCAR8-STK11KO spheroid formation and growth over time as imaged by IncuCyte ZOOM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b6e53fbaefa023e1fea21d0c276c58
https://doi.org/10.1158/1541-7786.22514406
https://doi.org/10.1158/1541-7786.22514406