Výsledky vyhledávání - "Trevor F. Carr"

Juvenile Myelomonocytic Leukemia Presenting With Features of Neonatal Hemophagocytic Lymphohistiocytosis and Cutaneous Juvenile Xanthogranulomata and Successfully Treated With Allogeneic Hemopoietic Stem Cell Transplant

Autor: Mary Judge, Robert Wynn, Anna Kelsey, Deepa R. J. Arachchillage, Bronwyn Kerr, Trevor F. Carr, Kay C. Hawkins

Publikováno v: Journal of Pediatric Hematology/Oncology. 32:152-155

Juvenile xanthogranuloma (JXG) is rarely associated with either hemophagocytic lymphohistiocytosis (HLH) or juvenile myelomonocytic leukemia (JMML) and when in association with the latter there is usually neurofibromatosis type 1. We report a child w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17f2ce2462c77b32354d6efc639353a
https://doi.org/10.1097/mph.0b013e3181cf4575

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Use of Enzyme Replacement Therapy (Laronidase) before Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis I: Experience in 18 Patients

Autor: Robert Wynn, Trevor F. Carr, Joanne Page, J. Edmond Wraith, Simon Jones, Jean Mercer

Publikováno v: The Journal of Pediatrics. 154:135-139

We describe the use of enzyme replacement therapy in conjunction with hematopoietic stem cell transplantation in 18 consecutive patients with severe mucopolysaccharidosis type I. The survival and engraftment rate was 89% overall and 93% for the 15 pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711e12c437a0ffe27a584e81202e6e1a
https://doi.org/10.1016/j.jpeds.2008.07.004

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Improved Outcome From Invasive Adenovirus Infection in Pediatric Patients After Hemopoietic Stem Cell Transplantation Using Intensive Clinical Surveillance and Early Intervention

Autor: Ponni Sivaprakasam, Mary Coussons, Kenneth J. Mutton, Andrew Turner, Malcolm Guiver, Trevor F. Carr, Tasneem Khalid, A. Bailey, Robert Wynn, John D. Grainger

Publikováno v: Journal of Pediatric Hematology/Oncology. 29:81-85

Adenovirus is a common cause of morbidity and mortality after hemopoietic stem cell transplantation in children. Recently the incidence, risk factors, and outcome of such infections have been better defined using improved virologic detection methods,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a74efaf75c72a0c6f0e84d85ee2ad94
https://doi.org/10.1097/mph.0b013e318030875e

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A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelicFANCD1/BRCA2 mutations

Autor: Tara Clancy, Jill Clayton-Smith, Osborn B. Eden, Trevor F. Carr, Michael R. Green, William D. Fergusson, Hans Joenje, Annette L. Medhurst, Quinten Waisfisz, Stefan Meyer, Johan P. de Winter, Andrew M. Will, Lisa M. Barber, Fei Chen, G. Malcolm Taylor, Anneke B. Oostra

Publikováno v: Genes, Chromosomes and Cancer. 42:404-415

Fanconi anemia (FA) is a rare autosomal recessive disorder characterized by congenital and developmental abnormalities, hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC), and strong predisposition to acute myeloid leukemia (AML).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35146c67776fe64894f2efb611a097ca
https://doi.org/10.1002/gcc.20153

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Treosulfan-containing regimens achieve high rates of engraftment associated with low transplant morbidity and mortality in children with non-malignant disease and significant co-morbidities

Autor: Persis Amrolia, Robert Wynn, Brigit Greystoke, Sonia Bonanomi, Paul Veys, Maged I. Gharib, Nicholas Goulden, Mamta Jagani, Paru Naik, Mary Coussons, Tasneem Khalid, K Rao, Trevor F. Carr

Publikováno v: British journal of haematology. 142(2)

Treosulfan is an immuno-suppressive and myeloablative alkylating agent that has been introduced as a conditioning agent in stem cell transplantation (SCT). Most studies have been performed in adult patients with malignancy where a low incidence of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eee6d15f8369fbdaa9598108de10e4f
https://pubmed.ncbi.nlm.nih.gov/18492115

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Biochemical monitoring after haemopoietic stem cell transplant for Hurler syndrome (MPSIH): implications for functional outcome after transplant in metabolic disease

Autor: Karen Tylee, Trevor F. Carr, Alan Cooper, M. Thornley, Ed Wraith, Anne O'Meara, Jean Mercer, Heather J. Church, Rob Wynn

Publikováno v: Bone marrow transplantation. 39(4)

Hurler Syndrome is corrected by allogeneic BMT by the action of donor enzyme on recipient tissue. In this paper, we describe monitoring of 39 patients transplanted in two centres to determine donor chimerism, enzyme level and residual substrate - exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7ece2b6be3aebd3eb3aa3c17802d66
https://pubmed.ncbi.nlm.nih.gov/17220904

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The impact of monitoring Epstein-Barr virus PCR in paediatric bone marrow transplant patients: can it successfully predict outcome and guide intervention?

Autor: Malcolm Guiver, Trevor F. Carr, Andrew Turner, Maged I. Gharib, Hayley M. Greenfield, Andrew M. Will, Robert Wynn

Publikováno v: Pediatric bloodcancer. 47(2)

Background Epstein-Barr virus (EBV) associated lymphoproliferative disease is a complication of haemopoietic stem cell transplantation (HSCT). In certain groups (unrelated and mismatched donor transplants, T-cell depleted) the risk may be as high as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed6bb8dfe4f9f06f124929e956cd09c
https://pubmed.ncbi.nlm.nih.gov/16276525

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Retrovirally mediated correction of bone marrow-derived mesenchymal stem cells from patients with mucopolysaccharidosis type I

Autor: Trevor F. Carr, Melissa A. Baxter, Heather J. Church, Jonathan A. Deakin, Ilaria Bellantuono, Robert Wynn, Leslie J. Fairbairn, Kirsten G. Edington, J. Ed Wraith, G. T. N. Besley, Alan Cooper

Publikováno v: Blood. 99(5)

We have investigated the utility of bone marrow–derived mesenchymal stem cells (MSCs) as targets for gene therapy of the autosomal recessive disorder mucopolysaccharidosis type IH (MPS-IH, Hurler syndrome). Cultures of MSCs were initially exposed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a81e0d6db594357627e118fd72740ef
https://pubmed.ncbi.nlm.nih.gov/11861306

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Donor bone marrow from a sibling with inborn error of metabolism for treatment of acute leukaemia - clinical and biochemical consequences in the non-affected recipient

Autor: Rob Wynn, James E. Wraith, Bernadette Brennan, Trevor F. Carr, M. Thornley, Andrew M. Will, Stefan Meyer

Publikováno v: Bone marrow transplantation. 25(8)

Bone marrow transplantation (BMT) is increasingly used in an attempt to correct inborn errors of metabolism (IEM). However, little is known about effects of BMT from patients with IEM donating for non-affected recipients. We present data from a 8.5-y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fcea1bab9c04a5eeb1dfbb62ee269e
https://pubmed.ncbi.nlm.nih.gov/10808215

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