Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Trevor D McKee"'
Autor:
Valeria Ramaglia, Salma Sheikh-Mohamed, Karen Legg, Calvin Park, Olga L Rojas, Stephanie Zandee, Fred Fu, Olga Ornatsky, Eric C Swanson, David Pitt, Alexandre Prat, Trevor D McKee, Jennifer L Gommerman
Publikováno v:
eLife, Vol 8 (2019)
Multiple sclerosis (MS) is characterized by demyelinated and inflammatory lesions in the brain and spinal cord that are highly variable in terms of cellular content. Here, we used imaging mass cytometry (IMC) to enable the simultaneous imaging of 15+
Externí odkaz:
https://doaj.org/article/6def8078950146e587285cba613947c2
Autor:
Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John J. Nemunaitis, Dennis Kee, Avik Shome, Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar A. Grénman, Laura Caporiccio, Trevor D. McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan K. Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin G. Print, William R. Wilson, Michael A. Curran, Francis W. Hunter
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/b8265d5c0ed44e2583f6823d2b9a7cc0
Autor:
Meilin Chan, Licun Wu, Zhihong Yun, Trevor D. McKee, Michael Cabanero, Yidan Zhao, Mikihiro Kohno, Junichi Murakami, Marc de Perrot
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Chan et al find that the GITR-GITRL pathway is an important mechanism of autocrine proliferation in sarcomatoid mesothelioma that could explain their resistance to therapy. Blocking the GITR-GITRL pathway could therefore be a new therapeutic target f
Externí odkaz:
https://doaj.org/article/3c5ca878a66742d7a38438d115052146
Autor:
Iram Siddiqui, Jade Bilkey, Trevor D. McKee, Stefano Serra, Melania Pintilie, Trevor Do, Jing Xu, Ming-Sound Tsao, Steve Gallinger, Richard P. Hill, David W. Hedley, Neesha C. Dhani
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundTumor hypoxia is theorized to contribute to the aggressive biology of pancreatic ductal adenocarcinoma (PDAC). We previously reported that hypoxia correlated with rapid tumor growth and metastasis in patient-derived xenografts. Anticipating
Externí odkaz:
https://doaj.org/article/5add2d3f4e1b40eaa01da29e4b140543
Autor:
Giuseppe Novelli, Jing Liu, Michela Biancolella, Tonino Alonzi, Antonio Novelli, J. J. Patten, Dario Cocciadiferro, Emanuele Agolini, Vito Luigi Colona, Barbara Rizzacasa, Rosalinda Giannini, Benedetta Bigio, Delia Goletti, Maria Rosaria Capobianchi, Sandro Grelli, Justin Mann, Trevor D. McKee, Ke Cheng, Fatima Amanat, Florian Krammer, Andrea Guarracino, Gerardo Pepe, Carlo Tomino, Yacine Tandjaoui-Lambiotte, Yurdagul Uzunhan, Sarah Tubiana, Jade Ghosn, COVID Human Genetic Effort, French COVID Cohort Study Group, CoV-Contact Cohort, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Aurélie Cobat, Gai Elhanan, Joseph J. Grzymski, Andrea Latini, Sachdev S. Sidhu, Suresh Jain, Robert A. Davey, Jean-Laurent Casanova, Wenyi Wei, Pier Paolo Pandolfi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Abstract SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of the HECT-E3 ligase family members has been implicated in t
Externí odkaz:
https://doaj.org/article/44bb55f6f8b74b5bb5433d1a15eac416
Autor:
Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level
Externí odkaz:
https://doaj.org/article/130018a3112a40a29ff505012c3352a4
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100011- (2022)
The diagnosis of plasma cell neoplasms requires accurate, and ideally precise, percentages. This plasma cell percentage is often determined by visual estimation of CD138-stained bone marrow biopsies and clot sections. While not necessarily inaccurate
Externí odkaz:
https://doaj.org/article/3922012ff2064343aeb0c50655ef11db
Autor:
Naba Farooqui, Mark Zaidi, Lisa Vaughan, Trevor D. McKee, Eram Ahsan, Kevin D. Pavelko, Jose C. Villasboas, Svetomir Markovic, Timucin Taner, Nelson Leung, Haidong Dong, Mariam P. Alexander, Sandra M. Herrmann
Publikováno v:
Kidney International Reports. 8:628-641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12023b1a2636868f98122e64833d2d3b
https://doi.org/10.1016/j.ekir.2022.11.020
https://doi.org/10.1016/j.ekir.2022.11.020
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
The formation of hypoxic microenvironments within solid tumors is known to contribute to radiation resistance, chemotherapy resistance, immune suppression, increased metastasis, and an overall poor prognosis. It is therefore crucial to understand the
Externí odkaz:
https://doaj.org/article/4351ce7ab45f4736b74e98813d4ae2a6
Autor:
Susan J. Done, David McCready, Philippe L. Bedard, Martin J. Yaffe, John M.S. Bartlett, Naoto Hirano, Trevor D. McKee, Janina Kulka, Borbala Szekely, Christos Sotiriou, Christine Desmedt, Kela Liu, Rachel Peters, Yulia Yerofeyeva, Alison Cheung, Dan Wang, Fred Fu, Amanda Mao, Carrie Wei, Sabrina Manolescu, Eshetu G. Atenafu, Manjula Maganti, Shiyi Chen, Melanie Dawe, Ranju Nair, Zaldy Balde, Nisha Kanwar
Includes Supplemental Figure S1 and Supplemental Tables S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a87cf0cae47e412c6a49550fd467c7
https://doi.org/10.1158/0008-5472.22569151.v1
https://doi.org/10.1158/0008-5472.22569151.v1
