Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Trevor D Littlewood"'
Autor:
William R English, Heather Ireland-Zecchini, Andrew H Baker, Trevor D Littlewood, Martin R Bennett, Gillian Murphy
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195116 (2018)
Over expression of Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) in vascular smooth muscle cells (VSMCs) induces apoptosis and reduces neointima formation occurring after saphenous vein interposition grafting or coronary stenting. In studies to a
Externí odkaz:
https://doaj.org/article/b9a6a700721b4c0887a29d0b18bb7cb1
Autor:
Nicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Tania Campos, Yong-Won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Happloinsufficiency of Myc delays onset of cancers in mice. Here, the authors generated a mouse model of reversible cMyc hypomorphism and show that metronomic reduction of c-Myc in adult mice confers protection against cancers without side effects an
Externí odkaz:
https://doaj.org/article/f2edbfdb52b64070a843f6b7ca3e272f
Autor:
Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D. Littlewood, Gerard I. Evan, James E. Hudson, Catherine H. Wilson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
AimAdult mammalian cardiomyocytes are incapable of significant proliferation, limiting regeneration after myocardial injury. Overexpression of the transcription factor Myc has been shown to drive proliferation in the adult mouse heart, but only when
Externí odkaz:
https://doaj.org/article/d71cec92c0694be39048a32153f4f165
Autor:
Megan J. Bywater, Deborah L. Burkhart, Jasmin Straube, Arianna Sabò, Vera Pendino, James E. Hudson, Gregory A. Quaife-Ryan, Enzo R. Porrello, James Rae, Robert G. Parton, Theresia R. Kress, Bruno Amati, Trevor D. Littlewood, Gerard I. Evan, Catherine H. Wilson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Levels of the transcription factor Myc are deregulated in a range of different cancers. Here the authors show that Myc induces rapid transcriptional responses in some mouse tissues (liver), but not others (heart), and that transcriptional and prolife
Externí odkaz:
https://doaj.org/article/6242a1a22a8f47f48a5d16c07381d895
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
Myc de-activation triggers regression of KMp48 pancreatic tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180d1d15f0e2656bddab7079cef84052
https://doi.org/10.1158/2159-8290.22535017
https://doi.org/10.1158/2159-8290.22535017
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute activation of Myc in indolent pancreatic intraepithelial neoplasm (PanIN) epithelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb096b64ace5de33f588472ef8dc731
https://doi.org/10.1158/2159-8290.c.6547741.v1
https://doi.org/10.1158/2159-8290.c.6547741.v1
Autor:
Gerard I. Evan, Trevor D. Littlewood, Mark J. Arends, Laura Soucek, Lamorna Brown Swigart, Panayiotis Anastasiou, Steven Kupczak, Luca Pellegrinet, Tania Campos, Valentin J.A. Barthet, Roderik M. Kortlever, Nicole M. Sodir
Comparison of Myc-induced stromal phenotypes in KRasG12D-driven PanIN versus KRasG12D-driven lung adenoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2fea709b5d1ce5d40e1e10d17aaebe
https://doi.org/10.1158/2159-8290.22535011
https://doi.org/10.1158/2159-8290.22535011
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD induces proliferation to a similar extend as MycWT but is impaired in cellular transformation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a5dc71a4a60e365841b123aad69483
https://doi.org/10.1158/0008-5472.22411665
https://doi.org/10.1158/0008-5472.22411665
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38feb1aa6ffa33436fa76ac071ae6bf8
https://doi.org/10.1158/0008-5472.22411650
https://doi.org/10.1158/0008-5472.22411650
Autor:
Bruno Amati, Gerard I. Evan, Trevor D. Littlewood, Enrico Radaelli, Alessandro Verrecchia, Micol Ravà, Thelma Capra, Luca Rotta, Salvatore Bianchi, Camilla Recordati, Mirko Doni, Paola Nicoli, Valerio Bianchi, Luca Pellegrinet, Paola Pellanda, Theresia R. Kress
MycVD-sensitive genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0928aa0812ebd595332856a69dd4d82d
https://doi.org/10.1158/0008-5472.22411641.v1
https://doi.org/10.1158/0008-5472.22411641.v1