Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Trevor D Lamb"'
Autor:
Trevor D. Lamb, Timothy W. Kraft
Publikováno v:
Open Biology, Vol 10, Iss 1 (2020)
We develop an improved quantitative model of mammalian rod phototransduction, and we apply it to the prediction of responses to bright flashes of light. We take account of the recently characterized dimeric nature of PDE6 activation, where the config
Externí odkaz:
https://doaj.org/article/845593d09696437284f6ea6b639fcacf
Autor:
Trevor D. Lamb
Publikováno v:
The Journal of Physiology. 600:4585-4601
The detection of light in the vertebrate retina utilizes a duplex system of closely related rod and cone photoreceptors: cones respond extremely rapidly, and operate at 'photopic' levels of illumination, from moonlight upwards; rods respond much more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaadc4af985475ec0497ad7c7d01863
https://doi.org/10.1113/jp282058
https://doi.org/10.1113/jp282058
Autor:
Trevor D. Lamb, David M. Hunt
Publikováno v:
Open Biology, Vol 8, Iss 9 (2018)
We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GCAPs), the g
Externí odkaz:
https://doaj.org/article/2a4dd8cf8a33404a9f8a6e32f4d2181a
Autor:
Bilal M. Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Trevor D. Lamb, Klaus Peter Hofmann, Christian M. T. Spahn, Martin Heck
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding
Externí odkaz:
https://doaj.org/article/26903d7c4b264677880df6ed6c4f0dd0
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
We examine the implications of a recent report providing evidence that two transducins must bind to the rod phosphodiesterase to elicit significant hydrolytic activity. To predict the rod photoreceptor's electrical response, we use numerical simulati
Externí odkaz:
https://doaj.org/article/af0c0bfb807e4763b52083e9da0db2fc
Publikováno v:
Open Biology, Vol 8, Iss 1 (2018)
Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication. In this study, we determine the molecular phylogeny of the p
Externí odkaz:
https://doaj.org/article/fca04b9322984d23adcb524cb9dd2847
Autor:
Klaus Peter Hofmann, Trevor D. Lamb
Publikováno v:
Progress in Retinal and Eye Research. 93:101116
The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that exhibits remarkable physicochemical properties. This photopigment is ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85b72bec1d4d5b4747165c0d836b4ea
https://doi.org/10.1016/j.preteyeres.2022.101116
https://doi.org/10.1016/j.preteyeres.2022.101116
Autor:
Wayne I. L. Davies, Shaun P. Collin, Nicholas J. Hudson, Nathan S. Hart, Riccardo Natoli, Hardip R. Patel, David M. Hunt, Aaron Chuah, Scott C. Cutmore, Trevor D. Lamb
Publikováno v:
Molecular Biology and Evolution. 37:811-827
The diversity of color vision systems found in extant vertebrates suggests that different evolutionary selection pressures have driven specializations in photoreceptor complement and visual pigment spectral tuning appropriate for an animal’s behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be79f0b6b5d5cd9cdee045f6aaa260e1
https://doi.org/10.1093/molbev/msz269
https://doi.org/10.1093/molbev/msz269
Autor:
Trevor D. Lamb
Publikováno v:
Genome Biology and Evolution
A manually curated set of ohnolog families has been assembled, for seven species of bony vertebrates, that includes 255 four-member families and 631 three-member families, encompassing over 2,900 ohnologs. Across species, the patterns of chromosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb4337b9e3ac7cd284902a19ad605ec
https://doi.org/10.1093/gbe/evab044
https://doi.org/10.1093/gbe/evab044
Autor:
Trevor D. Lamb, Dan Cojoc, Vincent Torre, Fabio Falleroni, Yunzhen Li, Simone Mortal, Ulisse Bocchero
Publikováno v:
PLoS Biology
PLoS biology 18 (2020). doi:10.1371/journal.pbio.3000750
info:cnr-pdr/source/autori:Bocchero, Ulisse; Falleroni, Fabio; Mortal, Simone; Li, Yunzhen; Cojoc, Dan; Lamb, Trevor; Torre, Vincent/titolo:Mechanosensitivity is an essential component of phototransduction in vertebrate rods/doi:10.1371%2Fjournal.pbio.3000750/rivista:PLoS biology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:18
PLoS Biology, Vol 18, Iss 7, p e3000750 (2020)
PLoS biology 18 (2020). doi:10.1371/journal.pbio.3000750
info:cnr-pdr/source/autori:Bocchero, Ulisse; Falleroni, Fabio; Mortal, Simone; Li, Yunzhen; Cojoc, Dan; Lamb, Trevor; Torre, Vincent/titolo:Mechanosensitivity is an essential component of phototransduction in vertebrate rods/doi:10.1371%2Fjournal.pbio.3000750/rivista:PLoS biology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:18
PLoS Biology, Vol 18, Iss 7, p e3000750 (2020)
Photoreceptors are specialized cells devoted to the transduction of the incoming visual signals. Rods are able also to shed from their tip old disks and to synthesize at the base of the outer segment (OS) new disks. By combining electrophysiology, op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136b878b8ab7a069ed165a392d2637b5
http://europepmc.org/articles/PMC7384764
http://europepmc.org/articles/PMC7384764