Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults.

Autor: Standley RA; AdventHealth Translational Research Institute, Orlando, Florida., Distefano G; AdventHealth Translational Research Institute, Orlando, Florida., Trevino MB; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida., Chen E; BERG LLC, Framingham, Massachusetts., Narain NR; BERG LLC, Framingham, Massachusetts., Greenwood B; BERG LLC, Framingham, Massachusetts., Kondakci G; BERG LLC, Framingham, Massachusetts., Tolstikov VV; BERG LLC, Framingham, Massachusetts., Kiebish MA; BERG LLC, Framingham, Massachusetts., Yu G; AdventHealth Translational Research Institute, Orlando, Florida., Qi F; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida., Kelly DP; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida.; Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia., Vega RB; AdventHealth Translational Research Institute, Orlando, Florida.; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida., Coen PM; AdventHealth Translational Research Institute, Orlando, Florida., Goodpaster BH; AdventHealth Translational Research Institute, Orlando, Florida.; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2020 Sep 16; Vol. 75 (9), pp. 1744-1753.

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy.

Autor: Trevino MB; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida., Zhang X; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida.; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida., Standley RA; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida., Wang M; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida., Han X; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida., Reis FCG; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida., Periasamy M; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida., Yu G; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida., Kelly DP; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida.; Cardiovascular Research Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Goodpaster BH; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida.; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida., Vega RB; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida.; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida., Coen PM; Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, Florida.; Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, Florida.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2019 Nov 01; Vol. 317 (5), pp. E899-E910. Date of Electronic Publication: 2019 Sep 03.

Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice.

Autor: Trevino MB; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Mazur-Hart D; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Machida Y; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., King T; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Nadler J; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Galkina EV; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Poddar A; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Dutta S; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507., Imai Y; Department of Internal Medicine (M.B.T., D.M.-H., Y.M., T.K., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Microbiology and Molecular Cell Biology (E.V.G.), Eastern Virginia Medical School, Norfolk, Virginia 23507; Department of Mathematics and Statistics (A.P.), Old Dominion University, Norfolk, Virginia 23529; and Leroy T. Canoles Cancer Research Center (S.D.), Eastern Virginia Medical School, Norfolk, Virginia 23507.

Publikováno v: Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2015 Oct; Vol. 29 (10), pp. 1414-25. Date of Electronic Publication: 2015 Aug 21.

Pancreatic islet neuropeptide Y overexpression has minimal effect on islet morphology and β-cell adaptation to high-fat diet.

Autor: Machida Y; Department of Internal Medicine (Y.M., C.B., D.R.H., S.M.R., E.G., M.B.T., J.N., Y.I.), Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia 23507; and Department of Medicine (R.A.), Division of Endocrinology, Diabetes, and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104., Bruinsma C, Hallinger DR, Roper SM, Garcia E, Trevino MB, Nadler J, Ahima R, Imai Y

Publikováno v: Endocrinology [Endocrinology] 2014 Dec; Vol. 155 (12), pp. 4634-40. Date of Electronic Publication: 2014 Oct 06.