Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Trever R Carter"'
Autor:
Sichen Chang, Jonathan W. Dickerson, Baker Logan A, Thomas M. Bridges, Craig W. Lindsley, Darren W. Engers, Aidong Qi, Jerri M. Rook, Aaron M. Bender, P. Jeffrey Conn, Katrina A. Bollinger, Colleen M. Niswender, Changho Han, Alice L. Rodriguez, Trever R Carter, Li Peng, Julie L. Engers, Jordan C. O’Neill, Matthew Spock, Katherine J. Watson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein, we report the SAR leading to the discovery of VU6028418, a potent M(4) mAChR antagonist with high subtype-selectivity and attractive DMPK properties in vitro and in vivo across multiple species. VU6028418 was subsequently ev
Autor:
Aaron T, Garrison, Douglas L, Orsi, Rory A, Capstick, David, Whomble, Jinming, Li, Trever R, Carter, Andrew S, Felts, Paige N, Vinson, Alice L, Rodriguez, Allie, Han, Krishma, Hajari, Hyekyung P, Cho, Laura B, Teal, Madeline G, Ragland, Masoud, Ghamari-Langroudi, Michael, Bubser, Sichen, Chang, Nathalie C, Schnetz-Boutaud, Olivier, Boutaud, Anna L, Blobaum, Daniel J, Foster, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley, Carrie K, Jones, Changho, Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M
Autor:
Aaron M, Bender, Trever R, Carter, Matthew, Spock, Alice L, Rodriguez, Jonathan W, Dickerson, Jerri M, Rook, Sichen, Chang, Aidong, Qi, Christopher C, Presley, Darren W, Engers, Joel M, Harp, Thomas M, Bridges, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 56
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR
Autor:
Achintyan Gangadharan, Alexsandra Espejo, Joya Chandra, Yusha Sun, Trever R. Carter, Cavan P. Bailey, Judith S. Leopold, Christopher Whitehead
Publikováno v:
Neuro Oncol
High grade gliomas (HGG) carry poor prognosis with median survival rates under 15 months post diagnosis. Due to dysregulation of kinase signaling pathways within these tumors, targeted kinase inhibition has been considered as a promising clinical str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85daa132e3837749b4ce478c30d3a8ff
https://europepmc.org/articles/PMC7651413/
https://europepmc.org/articles/PMC7651413/
Publikováno v:
Curr Cancer Drug Targets
The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that ensures cellular proteostasis by maintaining the folding, stabilization, activation, and degradation of over 400 client proteins. Hsp90 is not only critical for routine protein maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d69f5f4821e44df5c76a4987dcf343
https://europepmc.org/articles/PMC7502213/
https://europepmc.org/articles/PMC7502213/
Autor:
Jerri M. Rook, P. Jeffrey Conn, Aidong Qi, Aaron M. Bender, Matthew Spock, Colleen M. Niswender, Thomas M. Bridges, Sichen Chang, Trever R Carter, Craig W. Lindsley, Joel M. Harp, Christopher C Presley, Alice L. Rodriguez, Darren W. Engers, Jonathan W. Dickerson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 56:128479
In this manuscript, we report a series of chiral 6-azaspiro[2.5]octanes and related spirocycles as highly potent and selective antagonists of the muscarinic acetylcholine receptor subtype 4 (mAChR4). Chiral separation and subsequent X-ray crystallogr
Autor:
Christopher Whitehead, Yusha Y. Sun, Trever R. Carter, Judith S. Sebolt-Leopold, Joya Chandra, Cavan P. Bailey
Publikováno v:
Cancer Research. 79:3089-3089
High grade gliomas (HGG), including glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG), carry poor prognosis with median survival rates under 15 months post diagnosis. Due to dysregulation of the RTK/PI3K pathways within these tumors, inc
Autor:
Joya Chandra, Yusha Y. Sun, Judith S. Leopold, Alexsandra Espejo, Christopher Whitehead, Cavan P. Bailey, Trever R. Carter
Publikováno v:
Cancer Research. 78:5871-5871
High grade gliomas (HGGs) in adults and children confer very poor prognosis, with median survival rates under two years post diagnosis. Genetic alterations in receptor tyrosine kinases (RTKs) are seen in both adult and pediatric glioblastoma. Amplifi