Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Trever Bivona"'
Autor:
Asmin Tulpule, Shruti Menon, Marcus Breese, Yone Lin, Hannah Allegakoen, Shruthi Perati, Ann Heslin, Max Horlbeck, Jonathan Weissman, Alejandro Sweet-Cordero, Trever Bivona
The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader question of whether and how oncogenes create tumor-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39177f8b55363c3b73172d0395878bcd
https://doi.org/10.21203/rs.3.rs-2869150/v1
https://doi.org/10.21203/rs.3.rs-2869150/v1
Autor:
Rafael Rosell, Trever Bivona, Petros Giannikopoulos, Mayumi Ono, Miquel Taron, Santiago Viteri, Rosario Garcia-Campelo, Enric Carcereny, Enriqueta Felip, Margarita Majem, Teresa Moran, Jia Wei, Bartomeu Massuti, Radj Gervais, Niki Karachaliou, Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ana Drozdowskyj, Miguel Angel Molina, Carlota Costa
Purpose: Concomitant genetic alterations could account for transient clinical responses to tyrosine kinase inhibitors of the EGF receptor (EGFR) in patients harboring activating EGFR mutations.Experimental Design: We have evaluated the impact of pret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4837c3ad09f07f902c94f10e1af9463
https://doi.org/10.1158/1078-0432.c.6522344.v1
https://doi.org/10.1158/1078-0432.c.6522344.v1
Autor:
Rafael Rosell, Trever Bivona, Petros Giannikopoulos, Mayumi Ono, Miquel Taron, Santiago Viteri, Rosario Garcia-Campelo, Enric Carcereny, Enriqueta Felip, Margarita Majem, Teresa Moran, Jia Wei, Bartomeu Massuti, Radj Gervais, Niki Karachaliou, Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ana Drozdowskyj, Miguel Angel Molina, Carlota Costa
PDF file - 934K, Table S1. Quantification of T790M allele in our samples Table S2. Percentage of EGFR T790M mutation in each sample. Table S3. Results of the analysis of the T790M mutation in 705 paraffin-embedded lung tumor samples using our PNA met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8164a99a6b023480bd062badc5adb1e0
https://doi.org/10.1158/1078-0432.22451960
https://doi.org/10.1158/1078-0432.22451960
Publikováno v:
Cancer Research. 83:3878-3878
Introduction: Identifying parallel survival pathways or compensatory mechanisms that limit the response to targeted therapy is critical to discover effective combinatorial strategies for the treatment of lung cancer and to prevent emergence of drug r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58bc2249834d0091f48625e97e79c8a4
https://doi.org/10.1158/1538-7445.am2023-3878
https://doi.org/10.1158/1538-7445.am2023-3878
Autor:
Manasi Mayekar, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, Andrew Rowan, Maise Al Bakir, Clare Weeden, Caroline E. McCoach, Collin M. Blakely, Nuri Alpay Temiz, Ai Nagano, Daniel L. Kerr, Julia K. Rotow, Oriol Pich, Franziska Haderk, Michelle Dietzen, Carlos Martinez Ruiz, Bruna Almeida, Lauren Cech, Beatrice Gini, Joanna Przewrocka, Chris Moore, Miguel Murillo, Bjorn Bakker, Brandon Rule, Cameron Durfee, Shigeki Nanj, Lisa Tan, Lindsay K. Larson, Prokopios P. Argyris, William L. Brown, Johnny Yu, Carlos Gomez, Philippe Gui, Rachel I. Vogel, Elizabeth A. Yu, Nicholas J. Thomas, Subramanian Venkatesan, Sebastijan Hobor, Su Kit Chew, Nicholas McGranahan, Nnennaya Kanu, Eliezer M. Van Allen, Julian Downward, Reuben S. Harris, Trever Bivona, Charles Swanton
Publikováno v:
Cancer Research. 82:2197-2197
Introduction: Increasing our understanding of drivers of mutagenesis in lung cancer is critical in our efforts to prevent tumor reoccurrence and resistance. Results: Using the multi-region TRACERx lung cancer study, we uncovered that APOBEC3B is sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c49478ed5c7c84f95d81176cd804c0
https://doi.org/10.1158/1538-7445.am2022-2197
https://doi.org/10.1158/1538-7445.am2022-2197
Autor:
David Gonzalez-Martinez, Lee Roth, Thomas Mumford, Yael Mosse, Asmin Tulpule, Trever Bivona, Lukasz Jan Bugaj
Publikováno v:
Cancer Research. 82:848-848
Drug resistance remains a significant obstacle in the successful treatment of cancer, highlighting the critical need to understand how oncogenes and cancer drugs impact cell physiology and resistance development. EML4-ALK is a receptor tyrosine kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd13ef1bc67f7869b87aadc56ea5a1d
https://doi.org/10.1158/1538-7445.am2022-848
https://doi.org/10.1158/1538-7445.am2022-848
Autor:
Manasi K. Mayekar, Trever Bivona
Publikováno v:
Cancer Research. 77:LB-124
Oncogenic activation of the RAS-MAPK pathway is the underlying cause of the majority of lung adenocarcinomas. In these tumors, RAS-MAPK pathway activation occurs via diverse genetic alterations in upstream receptor tyrosine kinases such as EGFR and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132fc75b02177ec47666ac372e490f22
https://doi.org/10.1158/1538-7445.am2017-lb-124
https://doi.org/10.1158/1538-7445.am2017-lb-124