Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Treuner Uwe D"'
Autor:
Wei Meng, Martin L. Ogletree, Robert Zahler, James C. Sutton, Guohua Zhao, Steven M. Seiler, G. A. Jacobs, Arvind Mathur, Zulan Pi, Treuner Uwe D, Karen S. Hartl, Gregory S. Bisacchi, William A. Slusarchyk, Scott A. Bolton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2227-2231
Azetidinones such as BMS-363131 (2) and BMS-363130 (3), which contain a guanidine group in the C-3 side chain were previously shown to be very potent inhibitors of human tryptase with high selectivity versus other serine proteases, including trypsin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aed84872ee718c1328d0681d89f4806
https://doi.org/10.1016/j.bmcl.2004.02.011
https://doi.org/10.1016/j.bmcl.2004.02.011
Autor:
Bolton, Scott A., Sutton, James C., Anumula, Rushith, Bisacchi, Gregory S., Jacobson, Bruce, Slusarchyk, William A., Treuner, Uwe D., Wu, Shung C., Zhao, Guohua, Pi, Zulan, Sheriff, Steven, Smirk, Rebecca A., Bisaha, Sharon, Cheney, Daniel L., Wei, Anzhi, Schumacher, William A., Hartl, Karen S., Liu, Eddie, Zahler, Robert, Seiler, Steven M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 September 2013 23(18):5239-5243
Autor:
Karen S. Hartl, Steven M. Seiler, Guohua Zhao, William A. Slusarchyk, Eddie C.-K. Liu, Daniel L. Cheney, James Sutton, Robert Zahler, Rebecca A. Smirk, Scott A. Bolton, Steven Sheriff, Rushith Kumar Anumula, Zulan Pi, Jacobson Bruce L, Gregory S. Bisacchi, William A. Schumacher, Shung C. Wu, Treuner Uwe D, Sharon N. Bisaha, Anzhi Wei
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(18)
In this Letter, we describe the synthesis of several nonamidine analogs of biaryl acid factor VIIa inhibitor 1 containing weakly basic or nonbasic P1 groups. 2-Aminoisoquinoline was found to be an excellent surrogate for the benzamidine group (compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e308b8b54fe48668dfee00c12c8e60c5
https://pubmed.ncbi.nlm.nih.gov/23927973
https://pubmed.ncbi.nlm.nih.gov/23927973
Autor:
Robert Zahler, Martin L. Ogletree, William A. Slusarchyk, William A. Schumacher, Wei Meng, Guohua Zhao, Scott A. Bolton, Karen S. Hartl, Steven M. Seiler, Treuner Uwe D, G. A. Jacobs, Zulan Pi, Gregory S. Bisacchi, James C. Sutton, Ming-Hsing Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(21)
A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0394434fee92484ad442ecdf78ebb1a1
https://pubmed.ncbi.nlm.nih.gov/12372540
https://pubmed.ncbi.nlm.nih.gov/12372540
Autor:
Wei Meng, G. A. Jacobs, William A. Schumacher, James C. Sutton, William A. Slusarchyk, Robert Zahler, Martin L. Ogletree, Gregory S. Bisacchi, Steven M. Seiler, Scott A. Bolton, Treuner Uwe D, Zulan Pi, Karen S. Hartl, Guohua Zhao, Ming-Hsing Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(21)
The serine protease tryptase has been implicated in allergic and inflammatory diseases and associated with asthma. The synthesis and SAR of a series of N1-activated-4-carboxy azetidinones are described, resulting in identification of BMS-363131 (2) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa7b9a85d2a88a95d573703b8233fc0
https://pubmed.ncbi.nlm.nih.gov/12372541
https://pubmed.ncbi.nlm.nih.gov/12372541
Publikováno v:
The Journal of Antibiotics. 31:546-560
The synthesis and in vitro structure-activity relationship of 7-ureidoacetyl cephalosporins carrying various substituents in the 3-position, compounds that showed an enhanced broad spectrum of antibacterial activity, has been outlined. Contrary to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801507fedf2d5faf34fe6a2c7815e41
https://doi.org/10.7164/antibiotics.31.546
https://doi.org/10.7164/antibiotics.31.546
Autor:
Christopher M. Cimarusti, William A. Slusarchyk, Th. Denzel, Hermann Breuer, W. H. Koster, Treuner Uwe D
Publikováno v:
The Journal of antimicrobial chemotherapy. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80965a6e4a666319e472ed2a8953f6d8
https://pubmed.ncbi.nlm.nih.gov/7199044
https://pubmed.ncbi.nlm.nih.gov/7199044
Autor:
J. E. Dolfini, H. E. Applegate, M. G. Young, Treuner Uwe D, Christopher M. Cimarusti, William A. Slusarchyk, W. H. Koster, M. A. Ondetti, Hermann Breuer
Publikováno v:
The Journal of antibiotics. 31(6)
The synthesis and antibacterial activity in vitro of 7-methoxylated cephalosporins having a thienylureidoacetyl or a thienylglycyl C-7 side-chain are described. Acylation of 7 beta-amino-7-methoxycephems with a novel 2-aminooxazolone hydrochloride un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79b98830d9bf0ab08f57d7e07cc5b83
https://pubmed.ncbi.nlm.nih.gov/681237
https://pubmed.ncbi.nlm.nih.gov/681237