Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Trent R. Stewart"'
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Changes in Osteoblast, Chondrocyte, and Adipocyte Lineages Mediate the Bone Anabolic Actions of PTH and Small Molecule GSK-3 Inhibitor
Autor: Richard E. Higgs, Thomas A. Engler, Henry Uhlman Bryant, Ernst R. Dow, Mathias N'Cho, Bruce D. Gitter, Jude E. Onyia, Jianyong Shou, Trent R. Stewart, David L. Halladay, Tao Wei, T. John Martin, Yanfei L. Ma, Diane L. Sterchi, Amar Kumar, N.H. Kulkarni
Publikováno v: Journal of Cellular Biochemistry. 102:1504-1518
Parathyroid hormone (PTH) and glycogen synthase kinase-3 (GSK-3) inhibitor 603281-31-8, administered once daily increased bone formation in vivo. We investigated the molecular mechanisms of the anabolic responses of PTH and 603281-31-8 in rat osteope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6dfee062afef2e3f0ef7661e0c47e9
https://doi.org/10.1002/jcb.21374
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5
Influence ofADH1B polymorphism on alcohol use and its subjective effects in a Jewish population
Autor: Lucinda G. Carr, Ting-Kai Li, Trent R. Stewart, Howard J. Edenberg, Tatiana Foroud, Peter Castelluccio
Publikováno v: American Journal of Medical Genetics. 112:138-143
Class I alcohol dehydrogenases (ADHs) are the principal enzymes responsible for ethanol metabolism in humans. Genetic polymorphism at the ADH1B locus (old nomenclature ADH2) results in isozymes with quite different catalytic properties. The frequency
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3f614e51a80916f98e0b44acc14683
https://doi.org/10.1002/ajmg.10674
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6
An A/G Polymorphism in the Promoter of Mitochondrial Aldehyde Dehydrogenase (ALDH2): Effects of the Sequence Variant on Transcription Factor Binding and Promoter Strength
Autor: Mark J. Stewart, Daisy Zheng, Lucinda G. Carr, Trent R. Stewart, Adrienne Williams, Wan Yin Chou, David W. Crabb, Jane Pinaire
Publikováno v: Alcoholism: Clinical and Experimental Research. 23:963-968
Introduction: The strong protective effect of the ALDH2*2 mutation on risk of alcoholism suggests that other mutations that reduce mitochondrial aldehyde dehydrogenase (ALDH) activity in the liver might also deter drinking. This study describes a pol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de5c7d1be07df276f5e19535db9ec34
https://doi.org/10.1111/j.1530-0277.1999.tb04213.x
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7
The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene
Autor: Mark J. Stewart, Trent R. Stewart, David W. Crabb, Katrina M. Dipple
Publikováno v: Gene. 173:155-161
Mitochondrial aldehyde dehydrogenase (ALDH2) activity is produced at low levels in many tissues, with highest production in liver. Transfection assays using the first 600 bp of upstream DNA provided evidence for both positive and negative regulatory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a0b9798aa878809b084f136a0c51ae
https://doi.org/10.1016/0378-1119(96)00068-6
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8
Abstract A07: The identification of combinations for the CDK4 and CDK6 inhibitor, abemaciclib
Autor: Li-Chun Chio, Yue Webster, Teresa F. Burke, Phil Iversen, Jack A. Dempsey, Wenjuan Wu, Christoph Reinhard, Trent R. Stewart, Shih-Hsun Chen, Karsten Boehnke, Ian C. Smith, Sheng-Bin Peng, Sean Buchanan, Maria Jose Lallena, Alfonso De Dios, Gong Xueqian, Raquel Torres, Richard P. Beckmann
Publikováno v: Molecular Cancer Research. 14:A07-A07
We developed a combination screening protocol to look for synergistic interactions with abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4 and CDK6). Abemaciclib (LY2835219), has shown cytostatic effects in some cell lines while indu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e45c5e44b062f39f788dc7f83d032d98
https://doi.org/10.1158/1557-3125.cellcycle16-a07
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Abstract A24: Beta-klotho expression is associated with the antitumor activity of pan-FGFR inhibitor in human malignancies with FGF19 amplification
Autor: Sandra Nakasone, Sean Buchanan, Genshi Zhao, Ying Wang, Xueqian Gong, Yong G. Yue, Timothy R. Mack, Amelie Forest, Xuemei Guo, Ruslan D. Novosiadly, Christoph Reinhard, Trent R. Stewart
Publikováno v: Molecular Cancer Therapeutics. 14:A24-A24
Fibroblast growth factor receptor 4 (FGFR4) is an attractive target in Oncology. A gene encoding fibroblast growth factor 19 (FGF19), the main ligand of FGFR4, is frequently amplified (A) and/or overexpressed (OE) in human malignancies according to T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5cefc86d77fed68a8e41e2a9d172428c
https://doi.org/10.1158/1535-7163.targ-15-a24
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10
Optimization and validation of small quantity RNA profiling for identifying TNF responses in cultured human vascular endothelial cells
Autor: Xi Lin, Trent R. Stewart, Jianyong Shou, Jude E. Onyia, Lawrence M. Gelbert, Hui-Rong Qian
Publikováno v: Journal of pharmacological and toxicological methods. 53(2)
Affymetrix oligonucleotide microarrays are widely used in basic and applied research (Lander, E.S., (1999). Array of hope. Nature Genetics 21, 3-4; Lockhart, D.J.Winzeler, E.A. (2000) Genomics, gene expression and DNA arrays. Nature 405, 827-836.) Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bf1b5a94976207b9f34679d56ccbf2
https://pubmed.ncbi.nlm.nih.gov/15878830
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