Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Trent M Woodruff"'
Autor:
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 8, Pp n/a-n/a (2022)
Abstract Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect. Methods SARS‐CoV‐2 was inoculated into a human lepirudin‐anticoag
Externí odkaz:
https://doaj.org/article/fce3333fc3fd462e95eb7a2ae93b9833
Autor:
Sunita Gulati, Frank J Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Nancy A Nowak, Ronald P Taylor, Marina Botto, Xianbao He, Robin R Ingalls, Trent M Woodruff, Wen-Chao Song, Janine Schuurman, Peter A Rice, Sanjay Ram
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)
Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. C
Externí odkaz:
https://doaj.org/article/d50d01ed75774b0d843c0e7549972158
Autor:
Matthew Snelson, Devy Deliyanti, Sih Min Tan, Anna M. Drake, Cassandra de Pasquale, Vinod Kumar, Trent M. Woodruff, Jennifer L. Wilkinson-Berka, Melinda T. Coughlan
Publikováno v:
Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Background Dietary-resistant starch is emerging as a potential therapeutic tool to limit the negative effects of diabetes on the kidneys. However, its metabolic and immunomodulatory effects have not yet been fully elucidated. Methods Six-wee
Externí odkaz:
https://doaj.org/article/cd9801adaeb54c4aa4d47220bd44381f
Autor:
Helen L Barrett, Marta H Kubala, Katherin Scholz Romero, Kerina J Denny, Trent M Woodruff, H David McIntyre, Leonie K Callaway, Marloes Dekker Nitert
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104826 (2014)
Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large for gestational age with a higher percentage body fat. Elevated maternal lipids may contribute to this. Placental lipases such as lipoprotein lipase (LPL), end
Externí odkaz:
https://doaj.org/article/e53ffa888ef4407faab5d987ab59d923
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Huntington's disease (HD) is a debilitating neurodegenerative condition characterized by motor, cognitive and psychiatric abnormalities. Immune dysregulation, prominently featuring increased immune activity, plays a significant role in HD pathogenesi
Externí odkaz:
https://doaj.org/article/da04a90bbbbf43a8ad305b6a76474156
Autor:
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 3, Pp 100306- (2024)
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive. The complement system, a key effector of the innate immune syst
Externí odkaz:
https://doaj.org/article/1dd1912f28f94e758319c69b9a634afc
Autor:
Min Chen, Stephen R. Edwards, Dhiraj Maskey, Trent M. Woodruff, Stephen Tomlinson, David Reutens
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 663-681 (2023)
A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade in neurobehavioral outcomes and neuropathology af
Externí odkaz:
https://doaj.org/article/2ede2200b0034b69a923faab41e8b79f
Autor:
Xaria X. Li, Trent M. Woodruff
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102758- (2023)
Summary: The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we present a protocol to screen the effects of different agonists and antagonists on these receptors in vitro, using phosphorylated extracellular signal-regulat
Externí odkaz:
https://doaj.org/article/8355b7dd4a0d4d819a508b25a936509a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Despite increasing knowledge about the factors involved in the progression of diabetic complications, diabetic kidney disease (DKD) continues to be a major health burden. Current therapies only slow but do not prevent the progression of DKD.
Externí odkaz:
https://doaj.org/article/f8926c3f87304125b205bd88f995825e
Autor:
Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Dick J. Sjöström, Per H. Nilsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially l
Externí odkaz:
https://doaj.org/article/98f1b9d1f3a24517a729bb9b927be744