Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Trent D. Evans"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Adenosine-5’-triphosphate (ATP), the primary energy currency in cellular processes, drives metabolic activities and biosynthesis. Despite its importance, understanding intracellular ATP dynamics’ impact on bioproduction and exploiting it
Externí odkaz:
https://doaj.org/article/c7be302ddc504790b64edf79238fb668
Autor:
Ismail Sergin, Trent D. Evans, Xiangyu Zhang, Somashubhra Bhattacharya, Carl J. Stokes, Eric Song, Sahl Ali, Babak Dehestani, Karyn B. Holloway, Paul S. Micevych, Ali Javaheri, Jan R. Crowley, Andrea Ballabio, Joel D. Schilling, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Mohamed A. Zayed, Babak Razani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
Dysfunction of autophagy in plaque macrophages aggravates atherosclerosis. Here the authors show that induction of macrophage autophagy–lysosomal biogenesis either genetically by overexpression of the master transcriptional regulator of this proces
Externí odkaz:
https://doaj.org/article/2386c202410647229c348496bc117d5b
Autor:
Liang Fang, Johnie Hodge, Fatma Saaoud, Junfeng Wang, Stephen Iwanowycz, Yuzhen Wang, Yvonne Hui, Trent D. Evans, Babak Razani, Daping Fan
Publikováno v:
OncoImmunology, Vol 6, Iss 5 (2017)
Tumor microenvironment (TME) contains a variety of infiltrating immune cells. Among them, tumor-associated macrophages (TAMs) and their alternative activation contribute greatly to the progression of tumors. The mechanisms governing macrophage polari
Externí odkaz:
https://doaj.org/article/f0a42b1f3d64453eb3f67968a7f1c797
Autor:
Koki Takabatake, Abhinav Diwan, Yu Sheng Yeh, Brian J. DeBosch, Babak Razani, Jeremiah Stitham, Joan Tao, Joel D. Schilling, Slava Epelman, Se Jin Jeong, Irfan J. Lodhi, Astrid Rodriguez-Velez, Trent D. Evans, Xiangyu Zhang
Publikováno v:
Autophagy
The autophagy-lysosome system is an important cellular degradation pathway that recycles dysfunctional organelles and cytotoxic protein aggregates. A decline in this system is pathogenic in many human diseases including neurodegenerative disorders, f
Autor:
Hanrui Zhang, Muredach P. Reilly, Babak Razani, Xiangyu Zhang, Arturo Alisio, Nathan O. Stitziel, Reece Clark, Trent D. Evans, Eric Song
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: LIPA (lysosomal acid lipase) mediates cholesteryl ester hydrolysis, and patients with rare loss-of-function mutations develop hypercholesterolemia and severe disease. Genome-wide association studies of coronary artery disease have identifi
Publikováno v:
Antioxidants & Redox Signaling. 31:458-471
Significance: p62/SQSTM1 is a multifunctional scaffolding protein involved in the regulation of various signaling pathways as well as autophagy. In particular, p62/SQSTM1 serves as an essential adaptor to identify and deliver specific organelles and
Autor:
Bradley S. Fleenor, Rachel A. Gioscia-Ryan, Zachary S. Clayton, Trent D. Evans, Matthew J. Rossman, Lawrence C. Johnson, Melanie C. Zigler, Jason S. Eng, Douglas R. Seals
Publikováno v:
GeroScience
Aortic stiffening, assessed as pulse-wave velocity (PWV), increases with age and is an important antecedent to, and independent predictor of, cardiovascular diseases (CVD) and other clinical disorders of aging. Aerobic exercise promotes lower levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38426d1d4ba918de5172dc931ddb1194
https://europepmc.org/articles/PMC8050175/
https://europepmc.org/articles/PMC8050175/
Autor:
Daping Fan, Junfeng Wang, Yong Li, Qing Liu, E. Angela Murphy, Babak Razani, Yuzhen Wang, Trent D. Evans, Diego Altomare, Yongzhong Yao, Johnie Hodge
Publikováno v:
Journal for Immunotherapy of Cancer
BackgroundTumor-associated macrophages (TAMs) play key roles in the development of many malignant solid tumors including breast cancer. They are educated in the tumor microenvironment (TME) to promote tumor growth, metastasis, and therapy resistance.
Autor:
Astrid Rodriguez-Velez, Slava Epelman, Xiangyu Zhang, Trent D. Evans, Se Jin Jeong, Eric Song, Abhinav Diwan, Joel D. Schilling, Jan R. Crowley, Babak Razani, Conrad C. Weihl, Nathan O. Stitziel, Irfan J. Lodhi, Divya Kapoor, Bettina Mittendorfer, Daping Fan, Karyn B. Holloway, Sunny Chen, Ismail Sergin
Publikováno v:
Nature metabolism
High protein diets are commonly utilized for weight loss, yet have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein i
Autor:
Trent D. Evans, Fuzhong Zhang
Publikováno v:
Curr Opin Biotechnol
Bacteria within an isoclonal population display significant heterogeneity in metabolism, even under tightly controlled environmental conditions. Metabolic heterogeneity enables influential functions not possible or measurable at the ensemble scale. S