Three-stage formation of cap carbonates after Marinoan snowball glaciation consistent with depositional timescales and geochemistry

Autor: Trent B. Thomas, David C. Catling

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract At least two global “Snowball Earth” glaciations occurred during the Neoproterozoic Era (1000-538.8 million years ago). Post-glacial surface environments during this time are recorded in cap carbonates: layers of limestone or dolostone t

Externí odkaz: https://doaj.org/article/6289da1fdd81431ca5bd64aaf7819367

A nitrogen-rich atmosphere on ancient Mars consistent with isotopic evolution models

Autor: Hu, Renyu, Thomas, Trent B.

The ratio of nitrogen isotopes in the Martian atmosphere is a key constraint on the planet's atmospheric evolution. However, enrichment of the heavy isotope expected due to atmospheric loss from sputtering and photochemical processes is greater than

Externí odkaz: http://arxiv.org/abs/2202.04825

CRAF dimerization with ARAF regulates KRAS-driven tumor growth

Autor: Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B. Hinkle, David Kan, Ehud Segal, Jason E. Long, Tony Lima, Nicholas P.D. Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R. Junttila, Andrey S. Shaw, Mark Merchant, Matthew T. Chang, Donald S. Kirkpatrick, Shiva Malek

Publikováno v: Cell Reports, Vol 38, Iss 6, Pp 110351- (2022)

Summary: KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS

Externí odkaz: https://doaj.org/article/fa5d3d0fa6ab4799a1b8b428959ad8e4

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Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice.

Autor: Seymour BJ; Division of Rheumatology, Department of Medicine, and., Trent B; Division of Rheumatology, Department of Medicine, and., Allen BE; Division of Rheumatology, Department of Medicine, and., Berlinberg AJ; Division of Rheumatology, Department of Medicine, and., Tangchittsumran J; Division of Rheumatology, Department of Medicine, and., Jubair WK; Division of Rheumatology, Department of Medicine, and., Chriswell ME; Division of Rheumatology, Department of Medicine, and., Liu S; Division of Rheumatology, Department of Medicine, and., Ornelas A; Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Stahly A; Division of Rheumatology, Department of Medicine, and., Alexeev EE; Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Dowdell AS; Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Sneed SL; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Fechtner S; Division of Rheumatology, Department of Medicine, and., Kofonow JM; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Robertson CE; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Dillon SM; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Wilson CC; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Anthony RM; Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Frank DN; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Colgan SP; Mucosal Inflammation Program and Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kuhn KA; Division of Rheumatology, Department of Medicine, and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Dec 19; Vol. 134 (4). Date of Electronic Publication: 2023 Dec 19.