Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Trent M. Woodruff"'
Autor:
Jennifer Stables, Reiss Pal, Barry M. Bradford, Dylan Carter-Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M. Woodruff, Katharine M. Irvine, Kim M. Summers, Neil A. Mabbott, David A. Hume
Publikováno v:
Neurobiology of Disease, Vol 203, Iss , Pp 106743- (2024)
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disease-associat
Externí odkaz:
https://doaj.org/article/50e9fb735e7344ee8935456482dec788
Autor:
Matthew Snelson, Devy Deliyanti, Sih Min Tan, Anna M. Drake, Cassandra de Pasquale, Vinod Kumar, Trent M. Woodruff, Jennifer L. Wilkinson-Berka, Melinda T. Coughlan
Publikováno v:
Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Background Dietary-resistant starch is emerging as a potential therapeutic tool to limit the negative effects of diabetes on the kidneys. However, its metabolic and immunomodulatory effects have not yet been fully elucidated. Methods Six-wee
Externí odkaz:
https://doaj.org/article/cd9801adaeb54c4aa4d47220bd44381f
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Huntington's disease (HD) is a debilitating neurodegenerative condition characterized by motor, cognitive and psychiatric abnormalities. Immune dysregulation, prominently featuring increased immune activity, plays a significant role in HD pathogenesi
Externí odkaz:
https://doaj.org/article/da04a90bbbbf43a8ad305b6a76474156
Autor:
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 3, Pp 100306- (2024)
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive. The complement system, a key effector of the innate immune syst
Externí odkaz:
https://doaj.org/article/1dd1912f28f94e758319c69b9a634afc
Autor:
Min Chen, Stephen R. Edwards, Dhiraj Maskey, Trent M. Woodruff, Stephen Tomlinson, David Reutens
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 663-681 (2023)
A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade in neurobehavioral outcomes and neuropathology af
Externí odkaz:
https://doaj.org/article/2ede2200b0034b69a923faab41e8b79f
Autor:
Xaria X. Li, Trent M. Woodruff
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102758- (2023)
Summary: The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we present a protocol to screen the effects of different agonists and antagonists on these receptors in vitro, using phosphorylated extracellular signal-regulat
Externí odkaz:
https://doaj.org/article/8355b7dd4a0d4d819a508b25a936509a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Despite increasing knowledge about the factors involved in the progression of diabetic complications, diabetic kidney disease (DKD) continues to be a major health burden. Current therapies only slow but do not prevent the progression of DKD.
Externí odkaz:
https://doaj.org/article/f8926c3f87304125b205bd88f995825e
Autor:
Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. Woodruff, John D. Lambris, Tom E. Mollnes, Dick J. Sjöström, Per H. Nilsson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic capacity and can potentially l
Externí odkaz:
https://doaj.org/article/98f1b9d1f3a24517a729bb9b927be744
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial funct
Externí odkaz:
https://doaj.org/article/3e34e826125b49e68e8a93beb3225f67
Autor:
Thyago Bispo Leonel, Joel José Megale Gabrili, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, John D. Lambris, Denise V. Tambourgi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulop
Externí odkaz:
https://doaj.org/article/d4d0ce99312e44bebecbaeaf558136c0