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Clinical-Epidemiological Profile of Patients Initiating Intensive Statin Therapy for the Secondary Prevention of Vascular Disease in Spain

Autor: Macías Saint-Gerons D, de la Fuente Honrubia C, González Bermejo D, Montero D, Gil MJ, Salvador Sanz A, de Andrés-Trelles F, Catalá-López F

Publikováno v: REVISTA ESPANOLA DE SALUD PUBLICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Background: The new recommendations regarding the utilization of high potency statins (intensive therapy) for the treatment of cardiovascular disease have been based on the extrapolation of data coming from clinical trials. The objective is to descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b72f5ca53dda8d07779a6a70af6acfa2
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1535

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Models of spliceosomal intron proliferation in the face of widespread ectopic expression

Autor: Rodríguez-Trelles, F, Tarrío, R, Ayala, FJ

Publikováno v: Rodríguez-Trelles, F; Tarrío, R; & Ayala, FJ. (2006). Models of spliceosomal intron proliferation in the face of widespread ectopic expression. Gene, 366(2), 201-208. doi: 10.1016/j.gene.2005.09.004. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0s4817js

It is now certain that today living organisms can acquire new spliceosomal introns in their genes. The proposed sources of spliceosomal introns are exons, transposons, and other introns, including spliceosomal and group II self-splicing introns. Spli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c1436c3c46a7e6470f148331a1a04a79
http://www.escholarship.org/uc/item/0s4817js

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Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene

Autor: Rodriguez-Trelles, F, Tarrio, R, Ayala, Francisco J

Publikováno v: Rodriguez-Trelles, F; Tarrio, R; & Ayala, Francisco J. (2003). Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene. Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13413-13417. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0nm9h7kh

Gene duplication is a primary source of molecular substrate for the emergence of evolutionary novelties. The chances for redundant gene sequences to evolve new functions are small compared with the probability that the copies become disabled by delet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e0167a2b60143b5ec9ee0ed57233368d
http://www.escholarship.org/uc/item/0nm9h7kh

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Akademický článek

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New Drosophila introns originate by duplication

Autor: Tarrío, R, Rodríguez-Trelles, F, Ayala, FJ

Publikováno v: Tarrío, R; Rodríguez-Trelles, F; & Ayala, FJ. (1998). New Drosophila introns originate by duplication. Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1658-1662. doi: 10.1073/pnas.95.4.1658. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2mw9w4dc

We have analyzed the phylogenetic distribution of introns in the gene coding for xanthine dehydrogenase in 37 species, including 31 dipterans sequenced by us. We have discovered three narrowly distributed novel introns, one in the medfly Ceratitis ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::bfe771ecb59205944e32417997e14a7f
http://www.escholarship.org/uc/item/2mw9w4dc

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