The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

Autor: Treffers, Emmely E.^1,2 (AUTHOR), Tas, Ali¹ (AUTHOR), Scholte, Florine E. M.¹ (AUTHOR), de Ru, Arnoud H.² (AUTHOR), Snijder, Eric J.¹ (AUTHOR), van Veelen, Peter A.² (AUTHOR), van Hemert, Martijn J.¹ (AUTHOR) m.j.van_hemert@lumc.nl

Publikováno v: PLoS Pathogens. 2/27/2023, Vol. 18 Issue 2, p1-36. 36p.

Efficient —2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein

Autor: Fang, Ying, Treffers, Emmely E., Li, Yanhua, Tas, Ali, Sun, Zhi, van der Meer, Yvonne, de Ru, Arnoud H., van Veelen, Peter A., Atkins, John F., Snijder, Eric J., Firth, Andrew E.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2012 Oct . 109(43), 17321-17322.

Externí odkaz: https://www.jstor.org/stable/41829666

Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis

Autor: Phylipsen, Marion, Yamsri, Supawadee, Treffers, Emmely E., Jansen, Diahann T. S. L., Kanhai, Warsha A., Boon, Elles M. J., Giordano, Piero C., Fucharoen, Supan, Bakker, Egbert, Harteveld, Cornelis L.

Publikováno v: Phylipsen, M, Yamsri, S, Treffers, E E, Jansen, D T S L, Kanhai, W A, Boon, E M J, Giordano, P C, Fucharoen, S, Bakker, E & Harteveld, C L 2012, ' Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis ', Prenatal Diagnosis, vol. 32, no. 6, pp. 578-587 . https://doi.org/10.1002/pd.3864
Prenatal Diagnosis, 32(6), 578-587. John Wiley and Sons Ltd
Prenatal Diagnosis; Vol 32

Objective: The aim of this study was to develop a pyrophosphorolysis-activated polymerization (PAP) assay for non-invasive prenatal diagnosis (NIPD) of β-thalassemia major and sickle-cell disease (SCD). PAP is able to detect mutations in free fetal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::12dc3876ac7aa99f66a4a4021a36211b
https://research.vumc.nl/en/publications/3b8f43a8-889e-44cf-95be-115874e7d927

A novel role for poly(C) binding proteins in programmed ribosomal frameshifting

Autor: Napthine, Sawsan, Treffers, Emmely E, Bell, Susanne, Goodfellow, Ian, Fang, Ying, Firth, Andrew E, Snijder, Eric J, Brierley, Ian

Translational control through programmed ribosomal frameshifting (PRF) is exploited widely by viruses and increasingly documented in cellular genes. Frameshifting is induced by mRNA secondary structures that compromise ribosome fidelity during decodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::765372fbee95da8f741b4dcd525283d8