Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics.

Autor: Wei, Tian‐Hua¹ (AUTHOR), Lu, Meng‐Yi² (AUTHOR), Yao, Si‐Hui³ (AUTHOR), Hong, Yu‐Qi¹ (AUTHOR), Yang, Jin¹ (AUTHOR), Zhang, Meng‐Yuan¹ (AUTHOR), Yin, Yu‐Qi¹ (AUTHOR), Han, Yu‐Jie¹ (AUTHOR), Li, Qing‐Qing¹ (AUTHOR), Wang, Zi‐Xuan¹ (AUTHOR), Wang, Yi‐Bo¹ (AUTHOR), Tong, Zhen‐Jiang¹ (AUTHOR), Zhou, Yun¹ (AUTHOR), Dai, Wei‐Chen¹ (AUTHOR), Yu, Yan‐Cheng¹ (AUTHOR), Sun, Shan‐Liang^1,4 (AUTHOR) ssun@njucm.edu.cn, Yang, Ye⁵ (AUTHOR) yangye876@sina.com, Li, Nian‐Guang¹ (AUTHOR) linianguang@njucm.edu.cn, Shi, Zhi‐Hao⁶ (AUTHOR) shizhihao@cpu.edu.cn

Publikováno v: Medcomm: Oncology. Mar2024, Vol. 3 Issue 1, p1-40. 40p.

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Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.

Autor: Tokarski JS; From the Departments of Molecular Structure and Design., Zupa-Fernandez A; Immunosciences Biology., Tredup JA; Protein Science., Pike K; the Department of Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492., Chang C; From the Departments of Molecular Structure and Design., Xie D; Protein Science., Cheng L; Immunosciences Biology., Pedicord D; Leads Discovery and Optimization, and., Muckelbauer J; From the Departments of Molecular Structure and Design., Johnson SR; From the Departments of Molecular Structure and Design., Wu S; Protein Science., Edavettal SC; Protein Science., Hong Y; Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543 and., Witmer MR; Protein Science., Elkin LL; the Department of Leads Discovery and Optimization, Bristol-Myers Squibb Research and Development, Wallingford, Connecticut 06492., Blat Y; Leads Discovery and Optimization, and., Pitts WJ; Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543 and., Weinstein DS; Discovery Chemistry, Bristol-Myers Squibb Research and Development, Princeton, New Jersey 08543 and., Burke JR; Immunosciences Biology, james.burke@bms.com.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 Apr 24; Vol. 290 (17), pp. 11061-74. Date of Electronic Publication: 2015 Mar 11.

Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.

Autor: Wrobleski ST; Department of Immunology Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA. stephen.wrobleski@bms.com, Lin S, Hynes J Jr, Wu H, Pitt S, Shen DR, Zhang R, Gillooly KM, Shuster DJ, McIntyre KW, Doweyko AM, Kish KF, Tredup JA, Duke GJ, Sack JS, McKinnon M, Dodd J, Barrish JC, Schieven GL, Leftheris K

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Apr 15; Vol. 18 (8), pp. 2739-44. Date of Electronic Publication: 2008 Mar 04.