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Rationalizing mAb Candidate Screening Using a Single Holistic Developability Parameter.

Autor: Willis LF; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Trayton I; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Saunders JC; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Brùque MG; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Davis Birch W; School of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds LS2 9JT, U.K., Westhead DR; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K., Day K; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Bond NJ; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Devine PWA; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Lloyd C; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Kapur N; School of Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Leeds, Leeds LS2 9JT, U.K., Radford SE; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., Darton NJ; The Discovery Centre─AstraZeneca PLC, Cambridge CB2 0AA, U.K., Brockwell DJ; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.