A comprehensive measure of Golgi sphingolipid flux using NBD C 6 -ceramide: evaluation of sphingolipid inhibitors.

Autor: Lee AH; Department of Medicine, Stony Brook University, Stony Brook, NY, USA., Snider JM; Department of Medicine, Stony Brook University, Stony Brook, NY, USA., Moorthi S; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA., Coant N; Department of Pathology, Stony Brook University, Stony Brook, NY, USA., Trayssac M; Department of Medicine, Stony Brook University, Stony Brook, NY, USA., Canals D; Department of Medicine, Stony Brook University, Stony Brook, NY, USA., Clarke CJ; Department of Medicine, Stony Brook University, Stony Brook, NY, USA., Luberto C; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA., Hannun YA; Department of Medicine, Stony Brook University, Stony Brook, NY, USA; Department of Pathology, Stony Brook University, Stony Brook, NY, USA; Department of Medicine, The Northport Veterans Affairs Hospital, Northport, NY, USA. Electronic address: yusuf.hannun@stonybrookmedicine.edu.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Aug; Vol. 65 (8), pp. 100584. Date of Electronic Publication: 2024 Jun 24.

Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid.

Autor: Velazquez FN; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Hernandez-Corbacho M; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Trayssac M; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Stith JL; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Bonica J; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11790, USA., Jean B; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Pulkoski-Gross MJ; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11790, USA., Carroll BL; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11790, USA., Salama MF; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA; Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Hannun YA; Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA., Snider AJ; Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA. Electronic address: ashleysnider@arizona.edu.

Publikováno v: Cellular signalling [Cell Signal] 2021 Mar; Vol. 79, pp. 109875. Date of Electronic Publication: 2020 Dec 05.

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.

Autor: Trayssac M; Department of Medicine, Stony Brook University, Stony Brook, NY, USA.; Stony Brook Cancer Center, Stony Brook, NY, USA., Clarke CJ; Department of Medicine, Stony Brook University, Stony Brook, NY, USA. christopher.clarke@stonybrookmedicine.edu.; Stony Brook Cancer Center, Stony Brook, NY, USA. christopher.clarke@stonybrookmedicine.edu., Stith JL; Department of Medicine, Stony Brook University, Stony Brook, NY, USA.; Stony Brook Cancer Center, Stony Brook, NY, USA., Snider JM; Department of Medicine, Stony Brook University, Stony Brook, NY, USA.; Stony Brook Cancer Center, Stony Brook, NY, USA., Newen N; Department of Medicine, Stony Brook University, Stony Brook, NY, USA.; Stony Brook Cancer Center, Stony Brook, NY, USA., Gault CR; Virginia Mason Medical Center, Seattle, WA, USA., Hannun YA; Department of Medicine, Stony Brook University, Stony Brook, NY, USA. yusuf.hannun@stonybrookmedicine.edu.; Stony Brook Cancer Center, Stony Brook, NY, USA. yusuf.hannun@stonybrookmedicine.edu., Obeid LM; Department of Medicine, Stony Brook University, Stony Brook, NY, USA.; Stony Brook Cancer Center, Stony Brook, NY, USA.; Northport Veterans Affairs Medical Center, Northport, NY, USA.

Publikováno v: Cell death & disease [Cell Death Dis] 2021 Jan 04; Vol. 12 (1), pp. 27. Date of Electronic Publication: 2021 Jan 04.

The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—An Unconventional Ally in Cancer Treatment.

Autor: Ung, Johnson¹ (AUTHOR) ju7a@virginia.edu, Kassai, Miki² (AUTHOR) kassaim18@ecu.edu, Tan, Su-Fern^3,4 (AUTHOR) st4ub@virginia.edu, Loughran Jr., Thomas P.^3,4 (AUTHOR) djf2g@virginia.edu, Feith, David J.^3,4 (AUTHOR), Cabot, Myles C.² (AUTHOR) cabotm@ecu.edu

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9825. 24p.

Role of sphingolipids in senescence: implication in aging and age-related diseases.

Autor: Trayssac M; Stony Brook Cancer Center and Department of Medicine, Stony Brook University, Stony Brook, New York, USA., Hannun YA; Stony Brook Cancer Center and Department of Medicine, Stony Brook University, Stony Brook, New York, USA., Obeid LM; Stony Brook Cancer Center and Department of Medicine, Stony Brook University, Stony Brook, New York, USA.; Northport Veterans Affairs Medical Center, Northport, New York, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Jul 02; Vol. 128 (7), pp. 2702-2712. Date of Electronic Publication: 2018 Jul 02.