Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

Autor: Martial Ruat, Christian Beyer, Oliver Distler, Angelika Horn, Trayana Kireva, Cinzia Cordazzo, Michal Tomcik, Alfiya Akhmetshina, Clara Dees, Georg Schett, Katrin Palumbo-Zerr, Pawel Zerr, Jörg H W Distler

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2012, epub ahead of print. ⟨10.1136/annrheumdis-2011-200883⟩

ObjectivesTissue fibrosis is a leading cause of death in patients with systemic sclerosis (SSc). Effective antifibrotic treatments are not available. Here, the authors investigated inhibition of hedgehog signalling by targeting Smoothened (Smo) as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25475b453d88ed0f96f37645d419900
https://doi.org/10.1136/annrheumdis-2011-200883

Ucma, a Novel Secreted Cartilage-specific Protein with Implications in Osteogenesis

Autor: Cordula Surmann-Schmitt, Nadia Adam, Klaus von der Mark, Ursula Schlötzer-Schrehardt, Andreas Tagariello, Rainer Deutzmann, Patrik Önnerfjord, Uwe Dietz, Dick Heinegård, Jung Park, Trayana Kireva, Michael Stock

Publikováno v: Journal of Biological Chemistry. 283:7082-7093

Here we report on the structure, expression, and function of a novel cartilage-specific gene coding for a 17-kDa small, highly charged, and secreted protein that we termed Ucma (unique cartilage matrix-associated protein). The protein is processed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fef09c0fb0a3bdfb755ea8dd8e1e6fd
https://doi.org/10.1074/jbc.m702792200

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

Autor: Giovanna Muscogiuri, Georg Schett, James B. Meigs, Josef M. Penninger, Friedrich Oberhollenzer, Florian Kronenberg, Ulrike Billmeier, Georg Egger, Stefan Kiechl, Peter Willeit, Dirk Mielenz, Alexander R. Moschen, Enzo Bonora, Michael Knoflach, Johann Willeit, Trayana Kireva, Jürgen Wittmann, Aline Bozec, Michael Orthofer, Herbert Tilg, Agnes Mayr, Monika Summerer, Gian Pio Sorice, Julia Luther, Stefan Wirtz, Andrea Giaccari

Publikováno v: Nature Medicine
Nature Medicine; Vol 19

Stefan Kiechl and colleagues show that blockade of receptor activator of nuclear factor-κB (RANKL) signaling in hepatocytes by cell type–specific genetic deletion of its receptor promotes greater insulin sensitivity in both a genetic and a nutriti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b775951dc5d3bdfee0f0f7822c6a4b5
http://hdl.handle.net/11562/581351

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Autor: Alfiya Akhmetshina, Katrin Palumbo, Trayana Kireva, Jörg H W Distler, Georg Schett, Anika Sadowski, Pawel Zerr, Ormond A. MacDougald, Jochen Zwerina, Christina Bergmann, Holm Schneider, Christian Beyer, Marc Oliver Riener, Oliver Distler, Clara Dees, Angelika Horn, Paulius Venalis

Publikováno v: Nature Communications

The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here we demonstrate a novel link between transforming growth fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45fd5e2e1eaf825df05a5f726404172
https://pubmed.ncbi.nlm.nih.gov/22415826

B-cell infiltrates induce endosteal bone formation in inflammatory arthritis

Autor: Georg Schett, Josef S Smolen, Andreas Brandl, Trayana Kireva, Karin Polzer, Jochen Zwerina, Silvia Hayer

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 23(10)

The objective of this study was to investigate the function of inflammatory bone marrow infiltrates found in vicinity to joints affected by inflammatory arthritis. These bone marrow infiltrates are rich in B cells and emerge at the interphase between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d3de5af6624d997bcc68ce57498e10
https://pubmed.ncbi.nlm.nih.gov/18505368