Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Travis T, Wager"'
Autor:
Bo Feng, Mark A. West, Jennifer L. Liras, Travis T. Wager, Nandini Chaturbhai Patel, Larry M. Tremaine, Jillian G. Johnson, Xinjun Hou
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2476-2483
It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), 2 major efflux transporters at blood-brain barrier. Thus, a physiologically based pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b16f8585e749e68fe7e4d8d2eacb68
https://doi.org/10.1016/j.xphs.2019.02.005
https://doi.org/10.1016/j.xphs.2019.02.005
Autor:
Nandini Chaturbhai Patel, Jennifer L. Liras, Patrick Trapa, Mark A. West, Tristan S. Maurer, Bo Feng, Patrick Robert Verhoest, Simone Sciabola, Travis T. Wager, Xinjun Hou
Publikováno v:
ACS chemical neuroscience. 12(6)
One of the objectives within the medicinal chemistry discipline is to design tissue targeting molecules. The objective of tissue specificity can be either to gain drug access to the compartment of interest (e.g., the CNS) for Neuroscience targets or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62bdff50f4f1777f718bef119679853
https://pubmed.ncbi.nlm.nih.gov/33651587
https://pubmed.ncbi.nlm.nih.gov/33651587
Autor:
Erica C. Dresselhaus, Leah Cleary, Gayathri Ramaswamy, Michael Marconi, Patrick Robert Verhoest, Edel Evrard, Uthpala Seneviratne, Christopher amEnde, Martin Pettersson, Ethan Lawrence Fisher, Jamison B. Tuttle, Lorraine F. Lanyon, Longfei Xie, Emily Sylvain, Travis T. Wager, Butler Todd W, John M. Humphrey, Claire M. Steppan, Simone Sciabola, Douglas Scott Johnson, Zhen Huang, Christopher J Helal, Michael Eric Green, Paramita Mukherjee
Publikováno v:
SSRN Electronic Journal.
Apolipoprotein E (apoE) is a 34 kDa key lipid transport protein in both the brain and the periphery. In the brain, it is produced predominantly by astrocytes and has been shown to play an important role in promoting neurite outgrowth and synaptogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::495ed8c5b171b21862cbc9cf6e9b701a
https://doi.org/10.2139/ssrn.3532040
https://doi.org/10.2139/ssrn.3532040
Autor:
Angela C. Doran, Cheng Chang, Shenping Liu, Butler Todd W, Travis T. Wager, Klaas Schildknegt, Lei Zhang, Michael Marconi, Jianke Li, Scot Richard Mente, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Joseph R. Hedde, Sarah Grimwood, Chakrapani Subramanyam, Paul Galatsis
Publikováno v:
ACS Chemical Neuroscience. 8:1995-2004
To enable the clinical development of our CNS casein kinase 1 delta/epsilon (CK1δ/e) inhibitor project, we investigated the possibility of developing a CNS positron emission tomography (PET) radioligand. For this effort, we focused our design and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7a24bb9dc9c4035e136f3bff24189
https://doi.org/10.1021/acschemneuro.7b00155
https://doi.org/10.1021/acschemneuro.7b00155
Autor:
Travis T. Wager, Dae Wook Kim, Cheng Chang, Angela C. Doran, George J DeMarco, Francois Gaudreault, Xian Chen, Jae Kyoung Kim
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 15, Iss 7, Pp n/a-n/a (2019)
Molecular Systems Biology, Vol 15, Iss 7, Pp n/a-n/a (2019)
In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day–night cycle. Failure of synchrony, which increases the risk for numerous chronic diseases, can be treated by phase adjustment of the circadian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d1d8ecbcd6538e5dbad3cd10f119ae
https://doi.org/10.15252/msb.20198838
https://doi.org/10.15252/msb.20198838
Autor:
Eric S. Marr, Simone Sciabola, Robin T. Nelson, Anabella Villalobos, Xiaomin Chen, Stefan Doerr, Yaozhong Zou, Michelle Vanase-Frawley, Noelia Ferruz, Gianni De Fabritiis, Travis T. Wager, Xinjun Hou, Bethany L. Kormos
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99456163627ecfc9f77045a007c6837
https://doi.org/10.1038/s41598-019-39694-1
https://doi.org/10.1038/s41598-019-39694-1
Autor:
Christopher W. am Ende, Ethan Lawrence Fisher, Erica C. Dresselhaus, Leah Cleary, John M. Humphrey, Edelweiss Evrard, Douglas S. Johnson, Patrick Robert Verhoest, Jamison B. Tuttle, Travis T. Wager, Longfei Xie, Emily Sylvain, Zhen Huang, Martin Pettersson, Uthpala Seneviratne, Lorraine F. Lanyon, Michael Marconi, Claire M. Steppan, Gayathri Ramaswamy, Simone Sciabola, Christopher John Helal, Michael Eric Green, Butler Todd W, Paramita Mukherjee
Publikováno v:
Cell Chem Biol
Summary Utilizing a phenotypic screen, we identified chemical matter that increased astrocytic apoE secretion in vitro. We designed a clickable photoaffinity probe based on a pyrrolidine lead compound and carried out probe-based quantitative chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb95efaa37463005f6dec0a4e78edca3
https://doi.org/10.1016/j.chembiol.2020.09.002
https://doi.org/10.1016/j.chembiol.2020.09.002
Autor:
Mark J. Majchrzak, Aarti Sawant-Basak, Christopher J. Schmidt, Nawshaba Nawreen, Thomas Allen Chappie, Rebecca E. O’Connor, Michelle Vanase-Frawley, Keith Dlugolenski, David Horton, David P. Nguyen, Bethany L. Kormos, Ramalakshmi Yegna Chandrasekaran, Travis T. Wager, Nancy C. Stratman, Elizabeth R. Dunn-Sims, Brian Samas, Andy N. Mead, Cathleen Hsu
Publikováno v:
ACS Chemical Neuroscience. 8:165-177
Dopamine receptor antagonism is a compelling molecular target for the treatment of a range of psychiatric disorders, including substance use disorders. From our corporate compound file, we identified a structurally unique D3 receptor (D3R) antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233def4cf409b94edafff8b7059d5f86
https://doi.org/10.1021/acschemneuro.6b00297
https://doi.org/10.1021/acschemneuro.6b00297
Publikováno v:
ACS Chemical Neuroscience. 7:767-775
Significant progress has been made in prospectively designing molecules using the central nervous system multiparameter optimization (CNS MPO) desirability tool, as evidenced by the analysis reported herein of a second wave of drug candidates that or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afa488427fef228551c51c10df2f80f
https://doi.org/10.1021/acschemneuro.6b00029
https://doi.org/10.1021/acschemneuro.6b00029
Autor:
Anthony Carlo, Bo Feng, Mark A. West, Jennifer L. Liras, Nandini Chaturbhai Patel, Thomas Y. K. Lau, Travis T. Wager, Matthew D. Troutman, Patrick Trapa, John P. Umland, Tristan S. Maurer
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(4)
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally acting or centrally restricted therapeutics. Previously, a comprehensive physiologically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ffe6cefd0f63fc6e3b6394cefb5bb2
https://pubmed.ncbi.nlm.nih.gov/30683809
https://pubmed.ncbi.nlm.nih.gov/30683809